Ho A M, Fraser I M, Suria D D
Can J Anaesth. 1987 Mar;34(2):178-81. doi: 10.1007/BF03015342.
A digitalized 75-year-old patient with postoperative renal failure demonstrated a progressive rise in serum digoxin concentration, peaking at 3.4 nmol X L-1 three days following discontinuance of the drug. This was accompanied by cardiac bradyarrhythmias. Although the serum digoxin concentration had already started to climb from a therapeutic level prior to the discontinuance of the drug, the unabated and substantial rise was consistent with a dramatic decrease in the apparent volume of distribution of digoxin accompanying acute renal failure. Serum digoxin levels were determined with fluorescence polarization immunoassay, which has an improved specificity when compared to the commonly used radioimmunoassays for digoxin.
一名75岁的数字化术后肾衰竭患者血清地高辛浓度逐渐升高，停药三天后达到峰值3.4 nmol/L。同时伴有心脏缓慢性心律失常。尽管血清地高辛浓度在停药前就已开始从治疗水平上升，但持续且大幅上升与急性肾衰竭时地高辛表观分布容积急剧减少一致。血清地高辛水平采用荧光偏振免疫分析法测定，与常用的地高辛放射免疫分析法相比，该方法特异性更高。
