Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Henan Provincial Key Laboratory of Nanocomposites & Applications, Institute of Nanostructured Functional Materials, Huanghe Science & Technology College, Zhengzhou, 450006, Henan, China.
Nanomedicine (Lond). 2024 Mar;19(6):537-555. doi: 10.2217/nnm-2023-0270. Epub 2024 Jan 31.
Ferroptosis has received increasing attention as a novel nonapoptotic programmed death. Recently, iron-based nanomaterials have been extensively exploited for efficient tumor ferroptosis therapy, as they directly release high concentrations of iron and increase intracellular reactive oxygen species levels. Breast cancer is one of the commonest malignant tumors in women; inhibiting breast cancer cell proliferation through activating the ferroptosis pathway could be a potential new target for patient treatment. Here, we briefly introduce the background of ferroptosis and systematically review the current cancer therapeutic strategies based on iron-based ferroptosis inducers. Finally, we summarize the advantages of these various ferroptosis inducers and shed light on future perspectives. This review aims to provide better guidance for the development of iron-based nanomaterial ferroptosis inducers.
铁死亡作为一种新型的非凋亡程序性细胞死亡方式受到了越来越多的关注。最近，铁基纳米材料被广泛用于有效的肿瘤铁死亡治疗，因为它们直接释放高浓度的铁并增加细胞内活性氧水平。乳腺癌是女性最常见的恶性肿瘤之一；通过激活铁死亡途径抑制乳腺癌细胞增殖可能成为患者治疗的一个潜在新靶点。在这里，我们简要介绍铁死亡的背景，并系统地综述基于铁基铁死亡诱导剂的当前癌症治疗策略。最后，我们总结了这些不同铁死亡诱导剂的优势，并展望了未来的研究方向。本综述旨在为铁基纳米材料铁死亡诱导剂的开发提供更好的指导。
