Prevalence, risk factors and genotyping of from endocervical specimens of infertile women at a tertiary care hospital, Vietnam.

BACKGROUND

To our knowledge, the prevalence, risk factors and distribution of genotypes are rarely mentioned in Vietnam. This study aimed to find the prevalence, risk factors and distribution of genotypes in infertile Vietnamese women.

METHODS

Endocervical swabs were collected from infertile women at the National Hospital of Obstetrics and Gynecology, Vietnam, between January 2020 and December 2021. All samples were analyzed for presence by Cobas 4800 CT/NG Test. Sequencing methods of A gene were used to determine the genotypes. An approximately 1200 bp A fragment was aligned with reference sequences from GenBank to identify the corresponding genotype.

RESULTS

The prevalence of endocervical infection was 15.6% of 761 participants. Factors independently associated with CT infection among infertile women, obtained by multivariate analysis, included abnormal vaginal discharge, cervicitis, lower abdominal pain, a history of ectopic pregnancy, having more than one sex partner, and age at first intercourse. Among the samples, genotype E (25.93%) was most frequently found, followed by genotypes D/Da (22.23%), F (13.58%), G/Ga (12.35%), J (12.35%), H (6.17%), K (3.70%), B/Ba (2.47%), and I/Ia (1.23%), respectively. Genotype F was related to types of infertility, and genotype H was associated with a history of miscarriage.

CONCLUSIONS

The present study indicated a high prevalence of in infertile Vietnamese women. The most common genotypes found in this population were E, D, and F. Our findings suggest that routine screening is necessary for early detection and performance of infection control methods.