Department of Nutritional Sciences, University of Georgia, Athens, GA, USA.
Department of Nutritional Sciences, University of Georgia, Athens, GA, USA; Department of Food Science and Technology, University of Georgia, Athens, GA, USA.
Nutr Res. 2024 Mar;123:88-100. doi: 10.1016/j.nutres.2024.01.006. Epub 2024 Jan 12.
Angiopoietin-like proteins (ANGPTLs) -3, -4, and -8 are regulators of lipid metabolism and have been shown to respond to changes in dietary fats. It is unknown how ANGPTLs respond to cottonseed oil (CSO) and olive oil (OO) consumption in a population with hypercholesterolemia. The purpose of this study was to determine the impact of CSO vs. OO consumption on fasting and postprandial ANGPTL responses in adults with hypercholesterolemia. We hypothesized that CSO would have lower fasting and postprandial ANGPTL responses compared with OO. Forty-two adults with high cholesterol completed a single-blind, randomized trial comparing CSO (n = 21) vs. OO (n = 21) diet enrichment. An 8-week partial outpatient feeding intervention provided ∼60% of the volunteers' total energy expenditure (∼30% of total energy expenditure as CSO or OO). The remaining 40% was not controlled. Fasting blood draws were taken at pre-, mid-, and postintervention visits. Volunteers consumed a high saturated fat meal followed by 5 hours of blood draws pre- and postvisits. Fasting ANGPTL3 had a marginally significant treatment by visit interaction (P = .06) showing an increase from pre- to postintervention in CSO vs. OO (CSO: 385.1 ± 27.7 to 440.3 ± 33.9 ng/mL; OO: 468.2 ± 38.3 to 449.2 ± 49.5 ng/mL). Both postprandial ANGPTL3 (P = .02) and ANGPTL4 (P < .01) had treatment by visit interactions suggesting increases from pre- to postintervention in OO vs. CSO with no differences between groups in ANGPTL8. These data show a worsening (increase) of postprandial ANGPTLs after the OO, but not CSO, intervention. This aligns with previously reported data in which postprandial triglycerides were protected from increases compared with OO. ANGPTLs may mediate protective effects of CSO consumption on lipid control. This trial was registered at clinicaltrials.gov (NCT04397055).
血管生成素样蛋白 (ANGPTLs)-3、-4 和 -8 是脂质代谢的调节剂，并且已经表明它们对膳食脂肪的变化有反应。尚不清楚在患有高胆固醇血症的人群中，棉籽油 (CSO) 和橄榄油 (OO) 的消耗如何影响 ANGPTLs。本研究的目的是确定 CSO 与 OO 消耗对高胆固醇血症成年人空腹和餐后 ANGPTL 反应的影响。我们假设 CSO 的空腹和餐后 ANGPTL 反应会低于 OO。42 名高胆固醇成年人完成了一项单盲、随机试验，比较了 CSO（n = 21）与 OO（n = 21）饮食强化。为期 8 周的部分门诊喂养干预提供了志愿者总能量消耗的约 60%（总能量消耗的约 30%作为 CSO 或 OO）。其余 40%不受控制。空腹采血分别在干预前、中和后进行。志愿者在访问前和访问后 5 小时内食用高饱和脂肪餐。空腹 ANGPTL3 具有治疗与访问的交互作用的边缘显著（P =.06），表明 CSO 与 OO 从干预前到干预后的增加（CSO：385.1 ± 27.7 至 440.3 ± 33.9 ng/mL；OO：468.2 ± 38.3 至 449.2 ± 49.5 ng/mL）。餐后 ANGPTL3（P =.02）和 ANGPTL4（P <.01）均具有治疗与访问的交互作用，提示 OO 与 CSO 相比，从干预前到干预后的增加，而 ANGPTL8 两组之间没有差异。这些数据表明，在用 OO 而不是 CSO 进行干预后，餐后 ANGPTLs 恶化（增加）。这与以前报道的数据一致，其中餐后甘油三酯的增加得到了保护，与 OO 相比。ANGPTLs 可能介导 CSO 消耗对脂质控制的保护作用。该试验在 clinicaltrials.gov 注册（NCT04397055）。
