Department of Energy and Power Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
Department of Energy and Power Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
J Therm Biol. 2024 Jan;119:103800. doi: 10.1016/j.jtherbio.2024.103800. Epub 2024 Jan 26.
A detailed understanding of the coupled thermo-mechanical interaction on the biological tissue irradiated by a pulse laser is essential for the existed therapeutic methods constructed on the photo-thermal effect, which will contribute to the design, characterization and optimization of strategies for delivering better treatment. The aim of present work is to explore the coupled thermo-mechanical behavior of a multi-layered skin tissue with temperature-dependent physical properties under the pulsed laser irradiation. A layered theoretical model involved variable physical parameters with temperature has been proposed firstly according to the generalized theory of thermo-elasticity with dual-phase lag mechanism. The numerical method based on an explicit finite difference scheme is then employed to predict the temporal and spatial distributions of the temperature, thermal deformation and stresses experienced to a short-pulse laser irradiation. On this basis, the effect of variable thermal and mechanical physical parameters of skin tissue on the coupled thermo-mechanical behavior and relative thermal damage has been evaluated.
深入了解脉冲激光辐照生物组织的热-力学相互作用对于基于光热效应构建的现有治疗方法至关重要，这将有助于设计、表征和优化更好的治疗策略。本工作旨在探索具有温度相关物理特性的多层皮肤组织在脉冲激光辐照下的热-力学行为。首先，根据具有双时滞机制的广义热弹性理论，提出了一个涉及随温度变化的物理参数的分层理论模型。然后，采用基于显式有限差分方案的数值方法来预测短脉冲激光辐照下的温度、热变形和应力的时空分布。在此基础上，评估了皮肤组织的热学和力学物理参数的变化对热-力学行为和相对热损伤的影响。
