Phadnis Akshay, Kumar Sumit, Srivastava Atul
Department of Mechanical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
Department of Mechanical Engineering, Indian Institute of Technology Bombay, Mumbai 400076, India.
J Therm Biol. 2016 Oct;61:16-28. doi: 10.1016/j.jtherbio.2016.08.002. Epub 2016 Aug 12.
The work presented in this paper focuses on numerically investigating the thermal response of gold nanoshells-embedded biological tissue phantoms with potential applications into photo-thermal therapy wherein the interest is in destroying the cancerous cells with minimum damage to the surrounding healthy cells. The tissue phantom has been irradiated with a pico-second laser. Radiative transfer equation (RTE) has been employed to model the light-tissue interaction using discrete ordinate method (DOM). For determining the temperature distribution inside the tissue phantom, the RTE has been solved in combination with a generalized non-Fourier heat conduction model namely the dual phase lag bio-heat transfer model. The numerical code comprising the coupled RTE-bio-heat transfer equation, developed as a part of the current work, has been benchmarked against the experimental as well as the numerical results available in the literature. It has been demonstrated that the temperature of the optical inhomogeneity inside the biological tissue phantom embedded with gold nanoshells is relatively higher than that of the baseline case (no nanoshells) for the same laser power and operation time. The study clearly underlines the impact of nanoshell concentration and its size on the thermal response of the biological tissue sample. The comparative study concerned with the size and concentration of nanoshells showed that 60nm nanoshells with concentration of 5×10mm result into the temperature levels that are optimum for the irreversible destruction of cancer infected cells in the context of photo-thermal therapy. To the best of the knowledge of the authors, the present study is one of the first attempts to quantify the influence of gold nanoshells on the temperature distributions inside the biological tissue phantoms upon laser irradiation using the dual phase lag heat conduction model.
本文所展示的工作聚焦于对嵌入金纳米壳的生物组织模型的热响应进行数值研究，该研究在光热疗法中有潜在应用，其目的是以对周围健康细胞造成最小损伤的方式破坏癌细胞。用皮秒激光对组织模型进行了辐照。采用辐射传递方程（RTE），利用离散坐标法（DOM）对光与组织的相互作用进行建模。为了确定组织模型内部的温度分布，将RTE与广义非傅里叶热传导模型（即双相滞后生物热传递模型）相结合求解。作为当前工作的一部分开发的包含耦合RTE - 生物热传递方程的数值代码，已与文献中的实验结果和数值结果进行了基准测试。结果表明，对于相同的激光功率和操作时间，嵌入金纳米壳的生物组织模型内光学不均匀性处的温度相对高于基线情况（无纳米壳）。该研究清楚地强调了纳米壳浓度及其尺寸对生物组织样本热响应的影响。关于纳米壳尺寸和浓度的对比研究表明，浓度为5×10mm的60nm纳米壳在光热疗法的背景下能使温度达到对癌症感染细胞进行不可逆破坏的最佳水平。据作者所知，本研究是首次尝试使用双相滞后热传导模型量化激光辐照后金纳米壳对生物组织模型内部温度分布的影响之一。
