School of Aeronautic Science and Engineering, Beihang University, Beijing, 100191, People's Republic of China.
Sci Rep. 2021 May 11;11(1):9958. doi: 10.1038/s41598-021-89395-x.
Thermal ablation is an efficient method of medical treatment, such as cancer therapy, wound closure, laser cutting, freckle removal and other treatments. In order to guarantee the curative effect and the safety of the patients, the thermal response of the tissue which is subjected to the heat source need to be carefully monitored. However, it is too difficult to achieve real-time monitoring on the full-field temperature. In the present study, efforts were made to build up a theoretical model for the prediction of the thermal response in the human skin. The Dual-Phase-Lag (DPL) bio-heat transfer model and the Henrique's burn assessment model were employed to describe the interaction of multi-pulse heat source and the skin. The repeated multi-pulse laser is a common heat source in the thermal treatment and the thermal responses of the skin would be complicated under the common effects of the non-Fourier effects and the multi-pulse source. The Green's function approach was used to solve the governing equations analytically. The closed-form solution for the temperature distribution of the skin was obtained and the thermal damage was estimated based on the temperature results. The influences of the biological parameters (the phase lags of the heat flux and the temperature gradient) and the heat source parameters (the pulse number and the duty ratio) on the temperature distribution, the burn degree and the irreversible burn depth of the irradiated region were discussed.
热消融是一种有效的治疗方法，例如癌症治疗、伤口闭合、激光切割、祛斑等治疗。为了保证疗效和患者的安全，需要仔细监测受热源影响的组织的热响应。然而，实现全场温度的实时监测非常困难。在本研究中，努力建立一个用于预测人体皮肤热响应的理论模型。采用双时相滞后（DPL）生物传热模型和 Henrique 烧伤评估模型来描述多脉冲热源与皮肤的相互作用。重复的多脉冲激光是热治疗中常见的热源，在非傅里叶效应和多脉冲源的共同作用下，皮肤的热响应会变得复杂。采用格林函数法对控制方程进行解析求解。得到了皮肤温度分布的闭式解，并根据温度结果估计了热损伤。讨论了生物参数（热流和温度梯度的相位滞后）和热源参数（脉冲数和占空比）对辐照区域温度分布、烧伤程度和不可逆烧伤深度的影响。
