Programa de Pós-graduação em Biologia Celular e do Desenvolvimento, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
J Appl Toxicol. 2024 Oct;44(10):1470-1477. doi: 10.1002/jat.4582. Epub 2024 Jan 31.
Lubricants play a pivotal role in human reproductive health, particularly concerning their impact on sperm parameters. In this systematic review, we assess the implications of both synthetic and natural or organic lubricants on sperm health and fertility, based on a compilation of 20 distinct studies. Synthetic lubricants, including K-Y Jelly, Replens, and Astroglide, predominantly containing ingredients like methylparaben and glycerin, have been linked to detrimental effects on sperm motility and chromatin integrity. Chemical characteristics, notably osmolality and pH, are central to understanding these effects. Despite the World Health Organization's osmolality recommendation of 380 mOsm/kg, many commercial products surpass this. Natural solutions offer varied results, while olive oil exhibits unfavorable effects on sperm health, egg white proves non-toxic, potentially benefitting sperm health. Conversely, Pre-Seed, widely endorsed in the research community, generally demonstrates minimal adverse impact on sperm. The review highlights the significance of lubricant selection in evidence-based reproductive strategies.
润滑剂在人类生殖健康中起着关键作用，特别是它们对精子参数的影响。在这项系统评价中，我们根据 20 项不同的研究，评估了合成润滑剂和天然或有机润滑剂对精子健康和生育能力的影响。合成润滑剂，包括 K-Y 果冻、Repliens 和 Astroglide，主要含有对羟基苯甲酸甲酯和甘油等成分，与精子活力和染色质完整性的有害影响有关。化学特性，特别是渗透压和 pH 值，是理解这些影响的关键。尽管世界卫生组织推荐的渗透压为 380mOsm/kg，但许多商业产品都超过了这一水平。天然解决方案的结果各不相同，而橄榄油对精子健康有不利影响，蛋清则无毒，可能有益于精子健康。相反，在研究界广泛认可的 Pre-Seed 通常对精子的不良影响最小。该综述强调了在基于证据的生殖策略中选择润滑剂的重要性。
