Pradit Lalita, Somsak Pareeya, Piromlertamorn Waraporn, Pantasri Tawiwan, Sanmee Usanee
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
CMEx Fertility Center, Center of Medical Excellence, Chiang Mai University, Chiang Mai 50200, Thailand.
JBRA Assist Reprod. 2025 Jul 30;29(2):311-316. doi: 10.5935/1518-0557.20240113.
To investigate the effects of five coital lubricants including KY jelly, Durex, Pre-seed, Vaseline, and Baby oil on sperm motility and vitality.
Raw semen samples from 20 normozoospermic donors were incubated in vaginal fluid simulant (VFS) controls and a 10% concentration of KY jelly, Durex, Pre-seed, Vaseline, and Baby oil. The sperm motility and vitality were evaluated immediately after mixing (0 minutes) and at 30 and 60 minutes.
Sperm motility significantly decreased immediately after mixing in all coital lubricants. Pre-seed demonstrated sperm parameters comparable to VFS at any incubation time. KY jelly, Vaseline, and Baby oil reduced the progressive sperm motility at a certain time, both 30 and 60 minutes in KY jelly, at only 30 minutes in Baby oil, and at only 60 minutes in Vaseline. Durex showed a significant decrease in sperm motility at any incubation time and significantly deteriorated sperm vitality at 60 minutes while other lubricants did not affect sperm vitality.
Pre-seed was the coital lubricant that had the least negative effect on sperm. It can be an appropriate coital lubricant for the couple who are trying to conceive when lubricant is indicated. In contrast, KY jelly and Durex are the coital lubricants that should be avoided, especially Durex which had the worst effect on both sperm motility and vitality.
研究包括KY胶、杜蕾斯、Pre-seed、凡士林和婴儿油在内的五种性交润滑剂对精子活力和生命力的影响。
将20名正常精子捐献者的新鲜精液样本分别置于阴道液模拟物（VFS）对照组以及10%浓度的KY胶、杜蕾斯、Pre-seed、凡士林和婴儿油中孵育。在混合后立即（0分钟）以及30分钟和60分钟时评估精子活力和生命力。
在所有性交润滑剂中，混合后精子活力立即显著下降。Pre-seed在任何孵育时间的精子参数均与VFS相当。KY胶、凡士林和婴儿油在一定时间降低了精子的前向运动能力，KY胶在30分钟和60分钟时出现这种情况，婴儿油仅在30分钟时出现，凡士林仅在60分钟时出现。杜蕾斯在任何孵育时间精子活力均显著下降，且在60分钟时精子生命力显著恶化，而其他润滑剂不影响精子生命力。
Pre-seed是对精子负面影响最小的性交润滑剂。对于有受孕需求且需要使用润滑剂的夫妇来说，它可能是一种合适的性交润滑剂。相比之下，KY胶和杜蕾斯是应避免使用的性交润滑剂，尤其是杜蕾斯，它对精子活力和生命力的影响最差。
