Omar M A, Motala A A, Jialal I, Seedat M A
Diabetes Res. 1986 Nov;3(9):483-5.
103 Indians (74 females, 29 males) with NIDDM diagnosed before age 30 yr on the basis of the revised WHO diagnostic criteria were studied in order to assess the prevalence of microvascular complications. The mean duration of NIDDM in the subjects was 11 yr (range 2-38 yr). 24 patients (23%) eventually required insulin therapy for control after a mean interval of 11.8 yr (range 5-38 yr). Diabetic retinopathy was present in 37 patients (35.9%), of whom 6 had proliferative retinopathy. Nephropathy was found in 16 patients (15.5%). The mean GFR of these patients was 46.8 ml/min, compared to a mean of 97.1 ml/min in 12 of the patients without nephropathy who had a similar mean duration of disease. The mean duration of disease in patients with retinopathy and nephropathy was 14.9 yr and 14.8 yr respectively. In the patients who eventually required insulin therapy both retinopathy (75%) and nephropathy (41%) were more common but the mean duration of disease in these patients was longer (16 yr vs 9 yr). This study has underlined the heterogeneity of NIDDM in the young, as microvascular complications are by no means uncommon in South African Indians with the disease.
为评估微血管并发症的患病率，我们对103例根据世界卫生组织修订诊断标准在30岁之前确诊为非胰岛素依赖型糖尿病（NIDDM）的印度人（74名女性，29名男性）进行了研究。研究对象的NIDDM平均病程为11年（范围2 - 38年）。24例患者（23%）最终在平均11.8年（范围5 - 38年）的间隔后需要胰岛素治疗来控制病情。37例患者（35.9%）存在糖尿病视网膜病变，其中6例有增殖性视网膜病变。16例患者（15.5%）发现有肾病。这些肾病患者的平均肾小球滤过率（GFR）为46.8 ml/分钟，而在12例病程平均时长相似但无肾病的患者中，平均GFR为97.1 ml/分钟。患有视网膜病变和肾病患者的平均病程分别为14.9年和14.8年。在最终需要胰岛素治疗的患者中，视网膜病变（75%）和肾病（41%）更为常见，但这些患者的平均病程更长（16年对9年）。这项研究突显了年轻NIDDM患者的异质性，因为在南非患有该病的印度人中微血管并发症绝非罕见。
