Chiumello G, Bognetti E, Meschi F, Carrà M, Balzano E
Istituto Scientifico Ospedale San Raffaele, Università degli Studi di Milano, Italy.
J Endocrinol Invest. 1989;12(8 Suppl 3):101-4.
212 insulin dependent young diabetics with mean age of 16 yr and mean diabetes duration of 9 yr, have been examined for prevalence of subclinical signs of microvascular disease. Prevalence of retinopathy is increased in subjects of older age when matched for diabetes duration. Subclinical abnormalities of peripheral nervous system, identified by neurophysiological techniques, are present in about 20% of patients. These abnormalities are mainly related to metabolic control as evaluated by HbA1c determination. Albumin excretion rate over 10 mcg/min is observed in about 40% of subjects and is related to increased blood pressure values and poor metabolic control.
对212名胰岛素依赖型年轻糖尿病患者进行了检查，这些患者的平均年龄为16岁，平均糖尿病病程为9年，以确定微血管疾病亚临床体征的患病率。在糖尿病病程匹配的情况下，年龄较大的患者视网膜病变患病率增加。通过神经生理学技术确定的外周神经系统亚临床异常在约20%的患者中存在。这些异常主要与通过糖化血红蛋白（HbA1c）测定评估的代谢控制有关。约40%的受试者观察到白蛋白排泄率超过10微克/分钟，且与血压值升高和代谢控制不佳有关。
