Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of Exercise and Health, Tianjin University of Sport, Tianjin, 301617, China.
Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Institute of Exercise and Health, Tianjin University of Sport, Tianjin, 301617, China.
Free Radic Biol Med. 2024 Mar;213:409-425. doi: 10.1016/j.freeradbiomed.2024.01.036. Epub 2024 Jan 29.
Skeletal muscle is a heterogeneous tissue composed of different types of muscle fibers, demonstrating substantial plasticity. Physiological or pathological stimuli can induce transitions in muscle fiber types. However, the precise regulatory mechanisms behind these transitions remains unclear. This paper reviews the classification and characteristics of muscle fibers, along with the classical mechanisms of muscle fiber type transitions. Additionally, the role of exercise-induced muscle fiber type transitions in disease intervention is reviewed. Epigenetic pathways mediate cellular adaptations and thus represent potential targets for regulating muscle fiber type transitions. This paper focuses on the mechanisms by which epigenetic modifications couple mitochondrial function and contraction characteristics. Reactive Oxygen Species (ROS) are critical signaling regulators for the health-promoting effects of exercise. Finally, we discuss the role of exercise-induced ROS in regulating epigenetic modifications and the transition of muscle fiber types.
骨骼肌是一种由不同类型肌纤维组成的异质性组织，具有显著的可塑性。生理或病理刺激可诱导肌纤维类型转变。然而，这些转变背后的确切调节机制尚不清楚。本文综述了肌纤维的分类和特征，以及经典的肌纤维类型转变机制。此外，还综述了运动诱导的肌纤维类型转变在疾病干预中的作用。表观遗传途径介导细胞适应性，因此代表了调节肌纤维类型转变的潜在靶点。本文重点讨论了表观遗传修饰与线粒体功能和收缩特性偶联的机制。活性氧（ROS）是运动促进健康效应的关键信号调节剂。最后，我们讨论了运动诱导的 ROS 在调节表观遗传修饰和肌纤维类型转变中的作用。
