Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway.
Neuroscience Laboratory, Cobrain Center, Yerevan State Medical University after M. Heratsi, 0025, 2 Koryun str, Yerevan, Armenia.
Mol Neurobiol. 2024 Sep;61(9):6328-6340. doi: 10.1007/s12035-024-03941-y. Epub 2024 Jan 31.
This article explores the potential link between endocrine-disrupting chemicals (EDCs), neuroinflammation, and the development of autism spectrum disorder (ASD). Neuroinflammation refers to the immune system's response to injury, infection, or disease in the central nervous system. Studies have shown that exposure to EDCs, such as bisphenol A and phthalates, can disrupt normal immune function in the brain, leading to chronic or excessive neuroinflammation. This disruption of immune function can contribute to developing neurological disorders, including ASD. Furthermore, EDCs may activate microglia, increasing pro-inflammatory cytokine production and astroglia-mediated oxidative stress, exacerbating neuroinflammation. EDCs may also modulate the epigenetic profile of cells by methyltransferase expression, thereby affecting neurodevelopment. This article also highlights the importance of reducing exposure to EDCs and advocating for policies and regulations restricting their use. Further research is needed to understand better the mechanisms underlying the link between EDCs, neuroinflammation, and ASD and to develop new treatments for ASD.
本文探讨了内分泌干扰化学物质（EDCs）、神经炎症与自闭症谱系障碍（ASD）发展之间的潜在联系。神经炎症是指中枢神经系统对损伤、感染或疾病的免疫系统反应。研究表明，接触双酚 A 和邻苯二甲酸酯等 EDCs 会破坏大脑中正常的免疫功能，导致慢性或过度的神经炎症。这种免疫功能的破坏可能导致包括 ASD 在内的神经发育障碍。此外，EDCs 可能会激活小胶质细胞，增加促炎细胞因子的产生和星形胶质细胞介导的氧化应激，从而加剧神经炎症。EDCs 还可以通过甲基转移酶表达来调节细胞的表观遗传特征，从而影响神经发育。本文还强调了减少接触 EDCs 的重要性，并倡导制定政策和法规来限制其使用。需要进一步研究以更好地了解 EDCs、神经炎症与 ASD 之间联系的机制，并开发 ASD 的新治疗方法。
