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墨西哥城一家三级护理精神病医院老年患者的苯二氮䓬类药物使用情况、功能、认知及嗜睡状况

Benzodiazepine Consumption, Functionality, Cognition, and Somnolence in Older Adults at a Tertiary Care Psychiatric Hospital in Mexico City.

作者信息

Montes-Castrejon Adolfo, Moncayo-Samperio Luis Gerardo, Flores-Ramos Monica

机构信息

Department of Education, National Institute of Psychiatry, Mexico City, MEX.

Division of Postgraduate Studies, National Autonomous University of Mexico, Mexico City, MEX.

出版信息

Cureus. 2024 Jan 30;16(1):e53252. doi: 10.7759/cureus.53252. eCollection 2024 Jan.

Abstract

BACKGROUND

The aging population in Mexico, particularly those aged 60 and above, faces challenges in healthcare, including potentially inappropriate prescriptions of benzodiazepines. Physiological changes in older adults make precise drug prescriptions crucial.

OBJECTIVE

This study aims to evaluate and compare functionality, cognition, and daytime somnolence in older adults using benzodiazepines versus non-users. Additionally, it outlines the demographic and clinical characteristics of both groups.

METHODS

A cross-sectional study enrolled 162 participants aged 60 and above, categorized as benzodiazepine consumers or non-consumers. Assessment tools included Lawton's Index, Montreal Cognitive Assessment, Epworth Sleepiness Scale, and Benzodiazepine Dependence Questionnaire. Statistical analysis employed t-tests and chi-square tests.

RESULTS

Benzodiazepine users (n=81) exhibited lower cognitive scores, increased sleepiness, and reduced daily living activities compared to non-users (n=81). Demographically, BZD users had lower education levels.

CONCLUSION

Benzodiazepine use in older adults is associated with cognitive decline, daytime somnolence, and functional limitations, emphasizing the need for cautious prescription practices and continual monitoring. This study contributes insights into the impact of benzodiazepines on the cognitive health of older adults in Mexico.

摘要

背景

墨西哥的老龄化人口,尤其是60岁及以上的人群,在医疗保健方面面临挑战,包括苯二氮䓬类药物可能存在的不适当处方。老年人的生理变化使得精确的药物处方至关重要。

目的

本研究旨在评估和比较使用苯二氮䓬类药物的老年人与未使用者在功能、认知和日间嗜睡方面的情况。此外,还概述了两组的人口统计学和临床特征。

方法

一项横断面研究招募了162名60岁及以上的参与者,分为苯二氮䓬类药物使用者或非使用者。评估工具包括劳顿指数、蒙特利尔认知评估、爱泼沃斯嗜睡量表和苯二氮䓬类药物依赖问卷。统计分析采用t检验和卡方检验。

结果

与未使用者(n = 81)相比,苯二氮䓬类药物使用者(n = 81)的认知得分较低、嗜睡增加且日常生活活动减少。在人口统计学方面,苯二氮䓬类药物使用者的教育水平较低。

结论

老年人使用苯二氮䓬类药物与认知衰退、日间嗜睡和功能受限有关,强调了谨慎处方和持续监测的必要性。本研究为苯二氮䓬类药物对墨西哥老年人认知健康的影响提供了见解。

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Anxiety disorders, benzodiazepine prescription, and incident dementia.焦虑症、苯二氮䓬类药物处方与新发痴呆症
J Am Geriatr Soc. 2023 Nov;71(11):3376-3389. doi: 10.1111/jgs.18515. Epub 2023 Jul 28.

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