Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.
Headache. 2024 Feb;64(2):141-148. doi: 10.1111/head.14663. Epub 2024 Feb 1.
To evaluate self-reported substance user profiles for individuals with migraine and compare these to the general population.
There is increasing attention to lifestyle influences such as substance use as presumed migraine triggers.
Data on substance use were collected by survey in a large migraine cohort and from the biannual survey in the general Dutch population for substances. A representative cohort of Dutch patients with migraine (n = 5176) and the Dutch general population (n = 8370) was included. Patients with migraine were subdivided into episodic (EM) and chronic migraine (CM). Substance consumption was compared between the general population and patients with migraine, and between migraine subgroups after standardization for sex and level of education.
Included patients with migraine were 83.4% female (4319/5176) and had a mean (standard deviation) age of 44.8 (11.3) years. Patients with migraine reported less illicit drug use (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.42-0.55; p < 0.001), less current and lifetime smoking (OR 0.60, 95% CI 0.55-0.65; p < 0.001 and OR 0.75, 95% CI 0.71-0.79; p < 0.001), and less current alcohol consumption (OR 0.66, 95% CI 0.62-0.70; p < 0.001) compared with the general population. Prevalence of substance use was compared between CM and EM participants and showed higher illicit drug use (OR 1.73, 95% CI 1.11-2.69; p = 0.011), higher current smoking (OR 1.61, 95% CI 1.22-2.11; p < 0.001) but less alcohol use (OR 0.54, 95% CI 0.43-0.68; p < 0.001) for participants with CM compared with EM. No differences were found for a history of smoking (OR 1.18, 95% CI 0.92-1.50, p = 0.19).
Individuals with migraine are less likely to use illicit drugs, smoke, or drink alcohol compared with the general population. Patients with CM less often consume alcohol, while they more often use illicit drugs and smoke compared to those with EM.
评估偏头痛患者自我报告的物质使用者特征，并将其与普通人群进行比较。
越来越多的人关注生活方式的影响，如物质使用，因为它们被认为是偏头痛的诱因。
通过对大型偏头痛队列进行调查以及对普通荷兰人群进行的两年一次的物质使用调查，收集物质使用数据。纳入了荷兰偏头痛代表性患者队列（n=5176）和荷兰普通人群队列（n=8370）。偏头痛患者分为发作性偏头痛（EM）和慢性偏头痛（CM）。将普通人群和偏头痛患者之间以及偏头痛亚组之间的物质消费进行比较，并进行了性别和教育程度标准化。
纳入的偏头痛患者中，83.4%为女性（4319/5176），平均（标准差）年龄为 44.8（11.3）岁。与普通人群相比，偏头痛患者报告的非法药物使用较少（比值比[OR]0.48，95%置信区间[CI]0.42-0.55；p<0.001），当前和终身吸烟较少（OR 0.60，95%CI 0.55-0.65；p<0.001 和 OR 0.75，95%CI 0.71-0.79；p<0.001），当前饮酒较少（OR 0.66，95%CI 0.62-0.70；p<0.001）。与 EM 参与者相比，CM 参与者的物质使用患病率较高，包括非法药物使用（OR 1.73，95%CI 1.11-2.69；p=0.011）、当前吸烟（OR 1.61，95%CI 1.22-2.11；p<0.001），但酒精使用较少（OR 0.54，95%CI 0.43-0.68；p<0.001）。CM 参与者的吸烟史（OR 1.18，95%CI 0.92-1.50，p=0.19）无差异。
与普通人群相比，偏头痛患者使用非法药物、吸烟或饮酒的可能性较小。与 EM 患者相比，CM 患者较少饮酒，而更多地使用非法药物和吸烟。
