Xian Bravou Medical Beauty Hospital, Xi'an, China.
Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
J Cosmet Dermatol. 2024 May;23(5):1613-1619. doi: 10.1111/jocd.16211. Epub 2024 Feb 1.
Tear trough filling is a popular facial rejuvenation procedure, and hyaluronic acid is typically used as the filler of choice. However, Tyndall's phenomenon, a common complication following hyaluronic acid injection, can occur, leading to skin discoloration of the lower eyelid.
This single-center, prospective, comparative clinical study aimed to evaluate the efficacy of collagen and hyaluronic acid injections in treating tear trough deformity.
Sixty patients were enrolled between June 2022 and January 2023. Patients were randomly allocated into three groups: Group A received hyaluronic acid, Group B received hyaluronic acid combined with collagen, and Group C received collagen alone. Baseline characteristics, including age, sex, and tear trough deformity grade were considered before therapy. Changes in tear trough deformity scores, Global Aesthetic Improvement Scores, and the presence of the Tyndall effect were analyzed at 1 and 3 months postinjection to determine differences among the three groups.
Baseline profiles of the three groups were similar. In the first month postinjection, there was no difference in the Global Aesthetic Improvement Scores and tear trough deformity between the three groups. However, in the third-month postinjection, there was a significant difference in scores between patients in Group C and those in Groups A or B. The Tyndall effect manifested in three patients in Group A, which was significantly different from that in Groups B and C.
The combined use of hyaluronic acid with collagen in injectable fillers corrected tear trough deformities and reduced the occurrence of the Tyndall phenomenon, which can be problematic with hyaluronic acid alone. Additionally, this combination may help overcome the disadvantage of a shorter retention period when using collagen alone.
泪槽填充是一种流行的面部年轻化手术，通常使用透明质酸作为首选填充物。然而，透明质酸注射后常见的并发症是丁达尔现象，可导致下眼睑皮肤变色。
本单中心、前瞻性、对照临床研究旨在评估胶原蛋白和透明质酸注射治疗泪槽畸形的疗效。
2022 年 6 月至 2023 年 1 月期间共纳入 60 例患者。患者随机分为三组：A 组接受透明质酸治疗，B 组接受透明质酸联合胶原蛋白治疗，C 组接受胶原蛋白单独治疗。治疗前考虑了基线特征，包括年龄、性别和泪槽畸形程度。在注射后 1 个月和 3 个月时分析泪槽畸形评分、整体美学改善评分和丁达尔效应的变化，以确定三组之间的差异。
三组的基线特征相似。注射后 1 个月，三组之间的整体美学改善评分和泪槽畸形无差异。然而，在注射后 3 个月，C 组患者的评分与 A 组或 B 组患者的评分存在显著差异。A 组有 3 例患者出现丁达尔现象，与 B 组和 C 组有显著差异。
在注射填充物中联合使用透明质酸和胶原蛋白可矫正泪槽畸形，并减少丁达尔现象的发生，而单独使用透明质酸可能会出现这种问题。此外，这种联合使用可能有助于克服单独使用胶原蛋白时保留时间较短的缺点。
