从 Franch. 中分离出的四种新糖苷。
Four new glycosides isolated from Franch.
作者信息
He Zhilong, Xu Yingjie, Jiang Li, Liu Chunhua, Sun Jia, Li Yueting, Huang Yong, Ma Xue, Li Yongjun
机构信息
School of Basic Medical Sciences, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guiyang, China.
出版信息
Nat Prod Res. 2025 Jul;39(13):3671-3676. doi: 10.1080/14786419.2024.2306487. Epub 2024 Feb 1.
Phytochemical investigation of the whole plant of afforded four new glycosides including three coumarin glycosides, Gerbelavinside A (), Gerbelavinside B () and Gerbelavinside C () and one acetophenone glycoside, Gerbelavinside F (). The structures of isolated compounds were elucidated by analysis of 1D and 2D NMR, HR-ESI-MS, acid hydrolysis, as well as comparing with the literature. The isolated compounds were examined the effects of nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells, and Gerbelavinside C presented a certain inhibitory activity.
对[植物名称]全株进行的植物化学研究得到了四种新的糖苷，包括三种香豆素糖苷，即格贝拉文苷A（）、格贝拉文苷B（）和格贝拉文苷C（），以及一种苯乙酮糖苷，格贝拉文苷F（）。通过一维和二维核磁共振分析、高分辨电喷雾电离质谱、酸水解以及与文献比较，阐明了分离得到的化合物的结构。对分离得到的化合物在脂多糖（LPS）诱导的RAW264.7巨噬细胞中抑制一氧化氮（NO）产生的作用进行了研究，格贝拉文苷C表现出一定的抑制活性。
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