中华雪胆块茎中的葫芦素苷类化合物。
Cucurbitane glycosides from Hemsleya chinensis tubers.
作者信息
Li Miaomiao, Chi Jun, Chen Manliang, Huang Na, Lian Feihe, Wang Zhimin, Dai Liping
机构信息
Henan University of Chinese Medicine, Henan Collaborative Innovation Center for Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou 450046, China; Engineering Technology Research Center for Comprehensive Development and Utilization of Authentic Medicinal Materials in Henan Province, Zhengzhou 450046, China.
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
出版信息
Fitoterapia. 2025 Jul;184:106653. doi: 10.1016/j.fitote.2025.106653. Epub 2025 May 30.
Six previously undescribed cucurbitane glycosides, hemchinosides A-F (1-6), along with eleven ones were isolated from Hemsleya chinensis tubers. Compounds 1-6 were characterized by the presence of one to three glucoses substitutions at C-26, and sometimes one glucose at C-3. The structures were confirmed by comprehensive UV, IR, HR-ESI-MS and NMR analyses, and absolute configurations were determined by a comparison of calculated and experimental ECD after acid-hydrolysis. The anti-inflammatory effects of the isolated compounds were further evaluated on lipopolysaccharides-induced RAW 264.7 cells.
从中华雪胆块茎中分离得到6个新的葫芦烷型糖苷，即雪胆皂苷A-F（1-6），以及11个已知化合物。化合物1-6的特征在于C-26位有1至3个葡萄糖取代，有时C-3位有1个葡萄糖取代。通过综合的紫外、红外、高分辨电喷雾电离质谱和核磁共振分析确定了其结构，并通过酸水解后计算和实验电子圆二色光谱的比较确定了绝对构型。进一步在脂多糖诱导的RAW 264.7细胞上评估了分离得到的化合物的抗炎作用。
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