卵巢中潜在药物毒性的分子位点。
Molecular loci for potential drug toxicity in ovaries.
作者信息
Richards J S
出版信息
Environ Health Perspect. 1986 Dec;70:159-61. doi: 10.1289/ehp.8670159.
Abstract
Ovarian follicular development is dependent on the actions and interactions of the pituitary gonadotropins, FSH and LH, and the ovarian steroid hormone, estradiol. Agents which might block the effects of these hormones would increase follicular atresia and reduce fertility. In addition, any substance toxic to the oocyte and its normal pattern of growth and meiosis would lead to reduced numbers of oocytes and follicles and impaired fertility. Autoimmune diseases may be one major cause of premature ovarian failure, and such diseases might be triggered by toxic external stimuli.
摘要
卵巢卵泡发育依赖于垂体促性腺激素FSH和LH以及卵巢甾体激素雌二醇的作用与相互作用。可能阻断这些激素作用的药物会增加卵泡闭锁并降低生育能力。此外，任何对卵母细胞及其正常生长和减数分裂模式有毒的物质都会导致卵母细胞和卵泡数量减少以及生育能力受损。自身免疫性疾病可能是卵巢早衰的一个主要原因，而这类疾病可能由有毒的外部刺激引发。
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