Giresun University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Giresun, Turkey.
Ondokuz Mayıs University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Samsun, Turkey.
Acta Clin Croat. 2023 Apr;62(1):19-24. doi: 10.20471/acc.2023.62.01.03.
The aim was to evaluate the effect, if any, of asymptomatic hyperuricemia on distal femoral cartilage thickness through musculoskeletal ultrasonography. A total of 66 participants were evaluated in this prospective, controlled study, including 33 asymptomatic hyperuricemic patients who presented at our outpatient clinic between January and April 2020, and 33 normouricemic subjects matched for age, gender and body mass index. Participants with systemic diseases affecting uric acid level such as chronic renal failure, psoriasis, gout, etc., participants using drugs that can affect uric acid level, and those with knee complaints were excluded from the study. Cartilage thickness measurements were taken using musculoskeletal ultrasonography from the right medial condyle, right lateral condyle, right intercondylar area, left medial condyle, left lateral condyle and left intercondylar area. Distal femoral cartilage thickness was lower in all measurement areas in the asymptomatic hyperuricemia group than in the normouricemic group (p<0.05 all). No correlation was noted between uric acid levels and cartilage thickness in all measurement areas in either the asymptomatic hyperuricemic or normouricemic group (p>0.05 all). We think that distal femoral cartilages seem to be thinner in participants with asymptomatic hyperuricemia. Longitudinal studies are needed to determine whether asymptomatic hyperuricemia will lead to knee osteoarthritis in individuals, although we believe that people with asymptomatic hyperuricemia should be informed accordingly in order to prevent development of potential knee osteoarthritis.
目的是通过肌肉骨骼超声评估无症状高尿酸血症对股骨远端软骨厚度的影响。本前瞻性对照研究共纳入 66 名参与者，包括 2020 年 1 月至 4 月期间在我院门诊就诊的 33 名无症状高尿酸血症患者和 33 名年龄、性别和体重指数匹配的血尿酸正常受试者。患有影响尿酸水平的系统性疾病（如慢性肾衰竭、银屑病、痛风等）、使用影响尿酸水平的药物或有膝关节症状的患者被排除在本研究之外。使用肌肉骨骼超声从右内侧髁、右外侧髁、右髁间区、左内侧髁、左外侧髁和左髁间区测量软骨厚度。无症状高尿酸血症组所有测量部位的股骨远端软骨厚度均低于血尿酸正常组（p<0.05 均）。在无症状高尿酸血症组和血尿酸正常组的所有测量部位中，尿酸水平与软骨厚度之间均无相关性（p>0.05 均）。我们认为无症状高尿酸血症患者的股骨远端软骨似乎更薄。需要进行纵向研究以确定无症状高尿酸血症是否会导致个体发生膝骨关节炎，但我们认为无症状高尿酸血症患者应相应知情，以预防潜在的膝骨关节炎的发生。
