Nasrabadi Mohammadbagher, Nazarian Maryam, Darroudi Majid, Marouzi Somayeh, Harifi-Mood Mohammad Sadra, Samarghandian Saeed, Farkhondeh Tahereh
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Toxicol Rep. 2024 Jan 6;12:148-157. doi: 10.1016/j.toxrep.2023.12.004. eCollection 2024 Jun.
Carbamate (CBs) is a class of insecticides which is being known as an important cause of intentional or accidental poisoning. CBs, cause carbamylation of acetylcholinesterase at neuronal synapses and neuromuscular junction. Exposure to CBs through skin contact, inhalation, or ingestion can result in significant cholinergic toxicity. This is due to the elevation of acetylcholine levels at ganglionic synapses found in both the sympathetic and parasympathetic nervous systems, as well as muscarinic receptors located in target organs of the parasympathetic nervous system, nicotinic receptors situated in skeletal muscle tissue, and the central nervous system. The association between human illnesses and environmental exposures to CBs have been extensively studied in several studies. Although CBs-triggered toxicity leads to overproduction of reactive oxygen species (ROS), the detailed association between the toxicity under CBs exposure and NFE2-related factor 2 (Nrf2) signaling pathways has not been completely clarified. In this review we aimed to summarize the latest findings on the functional interrelationship between carbamates compounds and Nrf2 signaling.
氨基甲酸酯类（CBs）是一类杀虫剂，被认为是导致故意或意外中毒的重要原因。CBs会使神经元突触和神经肌肉接头处的乙酰胆碱酯酶发生氨甲酰化。通过皮肤接触、吸入或摄入接触CBs可导致明显的胆碱能毒性。这是由于交感神经系统和副交感神经系统中神经节突触处的乙酰胆碱水平升高，以及副交感神经系统靶器官中的毒蕈碱受体、骨骼肌组织中的烟碱受体和中枢神经系统中的乙酰胆碱水平升高所致。在多项研究中，已经对人类疾病与环境接触CBs之间的关联进行了广泛研究。尽管CBs引发的毒性会导致活性氧（ROS）过度产生，但CBs暴露下的毒性与核因子E2相关因子2（Nrf2）信号通路之间的详细关联尚未完全阐明。在本综述中，我们旨在总结氨基甲酸酯类化合物与Nrf2信号之间功能相互关系的最新发现。
