Minervini Giuseppe, Franco Rocco, Marrapodi Maria Maddalena, Lo Giudice Antonino, Cicciù Marco, Ronsivalle Vincenzo
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Heliyon. 2024 Jan 7;10(2):e24208. doi: 10.1016/j.heliyon.2024.e24208. eCollection 2024 Jan 30.
Epidermolysis bullosa (EB) is a genetic syndrome afflicting skin and mucous membranes. The manifestation depends on the form: in mild conditions, occasionally, vesicular-bullous lesions of the oral cavity may be present, which heal spontaneously without leaving scars. Patients following joint rupture have scars that limit food intake and restrict quality of life. This study aims to evaluate the possibility of carrying out an implant therapy and the success rate of this therapy.
Until January 3, 2000, PubMed, Web of Science, and Lilacs were searched. Clinical studies were selected that considered implant therapy in patients with epidermolysis bullosa. Articles were therefore selected that addressed oral health and implant survival in patients with epidermolysis, with no differentiation between the various subtypes. A risk of bias assessment was performed through Cochrane.
Twenty-one studies were found after the investigation. Only five were chosen to create the current systematic study; 16 articles were skipped over. 10 papers were disregarded because they had been reviewed; 4 were ignored because they contained case studies; and two were omitted because they were not written in English. The results show that implant survival is at around 97%.
Patients with epidermolysis bullosa can be treated with implant therapy without the risk of an increased implant failure rate. Indicate the main conclusions or interpretations.
大疱性表皮松解症（EB）是一种累及皮肤和黏膜的遗传性综合征。其表现取决于类型：在轻度情况下，偶尔会出现口腔水疱性大疱性病变，可自行愈合且不留疤痕。关节破裂后的患者会留下疤痕，限制食物摄入并影响生活质量。本研究旨在评估进行种植治疗的可能性及其成功率。
检索截至2000年1月3日的PubMed、科学网和Lilacs。选择考虑对大疱性表皮松解症患者进行种植治疗的临床研究。因此，选取了涉及表皮松解症患者口腔健康和种植体存活情况的文章，未对不同亚型进行区分。通过Cochrane进行偏倚风险评估。
调查后发现21项研究。仅选择了5项来开展当前的系统研究；跳过了16篇文章。10篇论文因已被综述而被忽略；4篇因包含病例研究而被忽视；2篇因非英文撰写而被省略。结果显示种植体存活率约为97%。
大疱性表皮松解症患者可以接受种植治疗，且种植失败率不会增加。指出主要结论或解释。
