J Drugs Dermatol. 2024 Feb 1;23(2):SF37896s4-SF378969s10. doi: 10.36849/JDD.SF378969.
Antibiotics, topical and oral, are a cornerstone in the treatment of acnes vulgaris specifically by targeting the skin bacterium Cutibacterium acnes. Billions of individuals have received antibiotics as part of their treatment resulting in a worldwide pandemic of antibiotic resistance not only for C. acnes but also many other pathogens. With the increasing prevalence of acne and exponentially increasing utilization of antibiotics, prescribers must urgently embrace the notion of antibiotic stewardship to maintain the efficacy of acne treatments while attenuating the rise of resistance. This paper serves as an update on C. acnes resistance to antibiotics commonly employed in the treatment of acne and the necessity of implementing benzoyl peroxide in the treatment regimen as monotherapy or combination antibiotic therapies for overcoming and preventing resistance. J Drugs Dermatol. 2024;23:1(Suppl 2):s4-10.
抗生素，包括局部用和口服用抗生素，是治疗寻常痤疮的基石，特别是通过针对皮肤细菌痤疮丙酸杆菌。数以亿计的人接受了抗生素治疗，导致了抗生素耐药性的全球流行，不仅针对痤疮丙酸杆菌，而且针对许多其他病原体。随着痤疮的患病率不断增加和抗生素的使用呈指数级增长，医生必须紧急接受抗生素管理的概念，以维持痤疮治疗的疗效，同时减缓耐药性的上升。本文更新了痤疮丙酸杆菌对抗生素的耐药性，这些抗生素常用于治疗痤疮，并且需要将过氧化苯甲酰纳入治疗方案中，无论是单独使用还是与联合抗生素疗法一起使用，以克服和预防耐药性。J 皮肤病药物杂志。2024;23:1(增刊 2):s4-10。
