Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Department of Ophthalmology, The First Hospital of Hunan University of Chinese Medicine, Changsha, People's Republic of China.
Medicine (Baltimore). 2024 Feb 2;103(5):e37089. doi: 10.1097/MD.0000000000037089.
Gouty arthritis (GA) is an inflammatory disease caused by disorders of the purine metabolism. Although increasing number of drugs have been used to treat GA with the deepening of relevant research, GA still cannot be cured by simple drug therapy. The nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in the pathogenesis of GA. A considerable number of Chinese herbal medicines have emerged as new drugs for the treatment of GA. This article collected relevant research on traditional Chinese medicine monomers in the treatment of GA using NF-κB, GA, etc. as keywords; and conducted a systematic search of relevant published articles using the PubMed database. In this study, we analyzed the therapeutic effects of traditional Chinese medicine monomers on GA in the existing literature through in vivo and in vitro experiments using animal and cell models. Based on this review, we believe that traditional Chinese medicine monomers that can treat GA through the NF-κB signaling pathway are potential new drug development targets. This study provides research ideas for the development and application of new drugs for GA.
痛风性关节炎（GA）是一种由嘌呤代谢紊乱引起的炎症性疾病。尽管随着相关研究的深入，越来越多的药物被用于治疗 GA，但单纯的药物治疗仍无法治愈 GA。核因子-κB（NF-κB）信号通路在 GA 的发病机制中起着关键作用。相当数量的中草药已成为治疗 GA 的新药。本文以 NF-κB、GA 等为关键词，收集了关于中药单体治疗 GA 的相关研究，并利用 PubMed 数据库对相关已发表文章进行了系统检索。在这项研究中，我们通过动物和细胞模型的体内和体外实验，分析了现有文献中中药单体治疗 GA 的疗效。基于这篇综述，我们认为能够通过 NF-κB 信号通路治疗 GA 的中药单体是有潜力的新药开发靶点。本研究为 GA 新药的开发和应用提供了研究思路。
