Shunyi Hospital, Beijing Hospital of Traditional Chinese Medicine, Station East 5, Shunyi District, Beijing 101300, China.
Renal Division, Department of Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Harbin, China.
Biomed Pharmacother. 2023 Feb;158:114199. doi: 10.1016/j.biopha.2022.114199. Epub 2023 Jan 3.
As the final product of purine metabolism, excess serum uric acid (SUA) aggravates the process of some metabolic diseases. SUA causes renal tubule damage, interstitial fibrosis, and glomerular hardening, leading to gouty nephropathy (GN). A growing number of investigations have shown that NF-κB mediated inflammation and oxidative stress have been directly involved in the pathogenesis of GN. Traditional Chinese medicine's treatment methods of GN have amassed a wealth of treatment experience. In this review, we first describe the mechanism of NF-κB signaling pathways in GN. Subsequently, we highlight traditional Chinese medicine that can treat GN through NF-κB pathways. Finally, commenting on promising candidate targets of herbal medicine for GN treatment via suppressing NF-κB signaling pathways was summarized.
作为嘌呤代谢的终产物，过量的血清尿酸（SUA）会加重某些代谢疾病的进程。SUA 可导致肾小管损伤、间质纤维化和肾小球硬化，进而引发痛风性肾病（GN）。越来越多的研究表明，NF-κB 介导的炎症和氧化应激直接参与了 GN 的发病机制。中医药治疗 GN 的方法积累了丰富的治疗经验。在这篇综述中，我们首先描述了 NF-κB 信号通路在 GN 中的作用机制。随后，我们重点介绍了可通过 NF-κB 通路治疗 GN 的中药。最后，我们总结了通过抑制 NF-κB 信号通路，中草药治疗 GN 的有希望的候选靶点。
