PRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.
PRISM Research Institute, Technological University of the Shannon, N37 HD68 Athlone, Ireland.
Int J Pharm. 2024 Mar 25;653:123859. doi: 10.1016/j.ijpharm.2024.123859. Epub 2024 Feb 1.
This study explores the innovative production of personalized bilayer tablets, integrating two advanced manufacturing techniques: Droplet Deposition Modeling (DDM) and Injection Molding (IM). Unlike traditional methods limited to customizing dense bilayer medicines, our approach uses Additive Manufacturing (AM) to effectively adjust drug release profiles. Focusing on Caffeine and Paracetamol, we found successful processing for both DDM and IM using Caffeine formulation. The high viscosity of Paracetamol formulation posed challenges during DDM processing. Integrating Paracetamol formulation for the over-molding process proved effective, demonstrating IM's versatility in handling complex formulations. Varying infill percentages in DDM tablets led to distinct porosities affecting diverse drug release profiles in DDM-fabricated tablets. In contrast, tablets with high-density structures formed through the over-molding process displayed slower and more uniform release patterns. Combining DDM and IM techniques allows for overcoming the inherent limitations of each technique independently, enabling the production of bilayer tablets with customizable drug release profiles. The study's results offer promising insights into the future of personalized medicine, suggesting new pathways for the development of customized oral dosage forms.
本研究探索了个性化双层片剂的创新生产，整合了两种先进的制造技术：液滴沉积成型（DDM）和注塑成型（IM）。与传统方法仅限于定制密集型双层药物不同，我们的方法使用增材制造（AM）有效地调整药物释放曲线。本研究以咖啡因和扑热息痛为重点，发现使用咖啡因配方可以成功地进行 DDM 和 IM 处理。扑热息痛配方的高粘度在 DDM 加工过程中带来了挑战。对于复模工艺中的扑热息痛配方进行整合，证明了 IM 处理复杂配方的多功能性。在 DDM 片剂中改变填充百分比会导致明显的孔隙率，从而影响 DDM 制造片剂中不同的药物释放曲线。相比之下，通过复模工艺形成的高密度结构片剂显示出更慢且更均匀的释放模式。结合 DDM 和 IM 技术可以克服每种技术各自的固有局限性，从而能够生产具有可定制药物释放曲线的双层片剂。该研究结果为个性化药物的未来提供了有希望的见解，为定制口服剂型的开发开辟了新途径。
