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富血小板血浆注射对兔扩张中缝骨形成的影响：一项随机对照动物研究。

Effect of platelet rich plasma injection on bone formation in the expanded mid-palatal suture in rabbits: a randomized controlled animal study.

机构信息

Alexandria University, Alexandria, Egypt.

出版信息

BMC Oral Health. 2024 Feb 2;24(1):167. doi: 10.1186/s12903-024-03922-6.

DOI:10.1186/s12903-024-03922-6
PMID:38308245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10835953/
Abstract

BACKGROUND

Mid-Palatal suture expansion needs long retention period due to delayed bone formation in the expanded suture. Platelet-rich plasma (PRP) is a concentrated source of growth factors which increase bone formation. The aim of this study was to evaluate the effect of PRP injection on bone formation in expanded mid palatal suture in rabbits.

METHODS

In this prospective randomized controlled animal study, Twenty male rabbits (8-weeks-old) were subjected to mid-palatal expansion for 5 days. Animals were afterwards randomly divided into control group A & study group B. PRP was prepared and injected in the mid-palatal suture in animals belonging to group B only. After 6 weeks of retention, all animals were euthanized, and premaxillae were prepared for histological, histomorphometric and immunohistochemical analysis. Student t-test and paired t-test were used to compare the means of the two groups and within the same group respectively. Significance level set at p ≤ 0.05.

RESULTS

Histomorphometric analysis revealed a significant increase (p < 0.001) in the mean percentage of new bone in the study group (14.4%) compared to the control (1.4%). Suture width in study group was significantly wider than the control group (278.8 ± 9μms and 120.4 ± 3.4μms, p < 0.001). There was a significant increase in vascular density in study group than control group (309 ± 65.34 and 243.86 ± 48.1, p = 0.021). Osteopontin immuno-expression revealed a significant increase in optical density in study group than control group (0.21 ± 0.02 & 0.12 ± 0.01, p < 0.001).

CONCLUSIONS

In rabbit model, PRP injection can accelerate new bone formation in the expanded mid-palatal suture when compared to the control. This could hopefully result in a more stable midpalatal expansion and a reduced retention period.

摘要

背景

由于扩展缝中的骨形成延迟，中隔缝扩张需要长时间的保持期。富含血小板的血浆（PRP）是生长因子的浓缩来源，可增加骨形成。本研究旨在评估 PRP 注射对兔扩张中隔缝骨形成的影响。

方法

在这项前瞻性随机对照动物研究中，20 只 8 周龄雄性兔接受 5 天的中隔扩张。动物随后随机分为对照组 A 和研究组 B。仅向组 B 中的动物的中隔缝中注射 PRP。保留 6 周后，所有动物均被安乐死，制备上前颌骨进行组织学、组织形态计量学和免疫组织化学分析。分别使用学生 t 检验和配对 t 检验比较两组之间和同一组内的平均值。设定显著性水平为 p≤0.05。

结果

组织形态计量学分析显示，研究组的新骨平均百分比（14.4%）明显高于对照组（1.4%）（p<0.001）。研究组的缝宽度明显大于对照组（278.8±9μm 和 120.4±3.4μm，p<0.001）。研究组的血管密度明显高于对照组（309±65.34 和 243.86±48.1，p=0.021）。骨桥蛋白免疫表达显示，研究组的光密度明显高于对照组（0.21±0.02 和 0.12±0.01，p<0.001）。

结论

在兔模型中，与对照组相比，PRP 注射可加速扩张中隔缝中的新骨形成。这有望导致更稳定的中隔扩张和缩短保持期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/933c232ce49b/12903_2024_3922_Fig12_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/2564634f3576/12903_2024_3922_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/5cb3036d6e71/12903_2024_3922_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/1185da63a009/12903_2024_3922_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/4fd3fc192fc0/12903_2024_3922_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63ac/10835953/933c232ce49b/12903_2024_3922_Fig12_HTML.jpg

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