Yao Ke, Wu Yongzhi, Cai Jingyi, Wang Yigan, Shen Yu, Jing Dian, Zhao Zhihe
State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
School of Basic Medical Sciences, Chengdu University, Chengdu, China.
Heliyon. 2022 Sep 17;8(9):e10604. doi: 10.1016/j.heliyon.2022.e10604. eCollection 2022 Sep.
Platelet-rich concentrates, namely platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have recently shown potential roles in accelerating orthodontic tooth movement (OTM) and reducing treatment duration. Our study aims to systematically evaluate the effect of platelet-rich concentrates on OTM.
An electronic search of 11 databases, followed by a hand search of reference lists of eligible studies and related reviews, was conducted up to January 2022. Randomized controlled trials investigating OTM of patients with platelet-rich concentrates were included. Risk of bias was assessed by version 2 of Cochrane tool (RoB 2) for assessing risk of bias in randomized trials.
Among 715 records initially identified, 9 studies were included, of which 3 used PRP and the other 6 applied PRF. 7 studies supported a positive relationship between platelet-rich concentrates and OTM, but the other 2 studies reported a null and a negative effect of PRF, respectively. The overall qualities of evidence were moderate to high.
Platelet-rich concentrates as PRP and PRF seem to be effective in accelerating OTM at early stages, while their long-term efficacy remains controversial. Repeated application of platelet concentrates may increase the accelerated stability of OTM.
富含血小板的浓缩物，即富血小板血浆（PRP）和富血小板纤维蛋白（PRF），最近显示出在加速正畸牙齿移动（OTM）和缩短治疗时间方面的潜在作用。我们的研究旨在系统评价富含血小板的浓缩物对OTM的影响。
截至2022年1月，对11个数据库进行电子检索，随后人工检索符合条件的研究和相关综述的参考文献列表。纳入调查富含血小板浓缩物患者OTM的随机对照试验。采用Cochrane工具第2版（RoB 2）评估随机试验中的偏倚风险。
在最初识别的715条记录中，纳入了9项研究，其中3项使用PRP，另外6项应用PRF。7项研究支持富含血小板的浓缩物与OTM之间存在正相关关系，但另外2项研究分别报告PRF无作用和有负面影响。证据的总体质量为中等至高。
作为PRP和PRF的富含血小板的浓缩物似乎在早期加速OTM方面有效，但其长期疗效仍存在争议。重复应用血小板浓缩物可能会增加OTM的加速稳定性。
