Liu Lu, Kuang Qianyun, Zhou Jing, Long Hu
Department of Orthodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Diseases, Sichuan University, Sichuan, China.
Evid Based Dent. 2021 Jan;22(1):36-37. doi: 10.1038/s41432-021-0160-8.
Objectives To examine whether periodontal injection of platelet-rich plasma (PRP) could accelerate orthodontic tooth movement.Methods A split-mouth randomised controlled clinical trial was conducted among 16 female participants. Canines were retracted on 0.017 x 0.025-inch stainless steel archwires through closed-coil springs attached on first molars with mini-screws for anchorage preservation. The intervention side received PRP + CaCl2 solution and the control side CaCl2 only. Intraligamental injections were performed during the canine retraction period every three weeks (zero, three and six weeks). The rate of canine retraction was assessed through superimposition of digital models every month for a total of four months. Assessment of associated pain was conducted by questionnaire.Results During the four-month period, a faster rate of canine retraction was detected on the intervention side only for the first month. Following cessation of PRP injections, the rate of canine retraction on the intervention side was initially slower than and then similar to that on the control side. An increase of pain was reported on both sides.Conclusions PRP could accelerate orthodontic tooth movement in the short term with no prolonged effects.
目的 研究牙周注射富血小板血浆（PRP）是否能加速正畸牙齿移动。方法 对16名女性参与者进行了一项双侧随机对照临床试验。通过用微型螺钉固定在第一磨牙上的闭合弹簧，在0.017×0.025英寸的不锈钢弓丝上内收尖牙，以保留支抗。干预侧接受PRP+氯化钙溶液，对照侧仅接受氯化钙。在尖牙内收期间，每三周（零周、三周和六周）进行一次韧带内注射。通过每月对数字化模型进行叠加，共四个月，评估尖牙内收的速率。通过问卷调查评估相关疼痛情况。结果 在四个月期间，仅在第一个月检测到干预侧尖牙内收速率更快。停止PRP注射后，干预侧尖牙内收速率最初比对照侧慢，然后与对照侧相似。两侧均报告疼痛增加。结论 PRP可在短期内加速正畸牙齿移动，但无长期效果。
