水中运动方案与陆地运动方案对癌症相关疲劳、神经病变、活动和参与、生活质量以及癌症患者重返工作岗位的影响：一项随机对照试验的研究方案。

Effects of aquatic exercise program versus on-land exercise program on cancer-related fatigue, neuropathy, activity and participation, quality of life, and return to work for cancer patients: study protocol for a randomized controlled trial.

机构信息

Teachers for Students With Complex and Multiple Disabilities Track, The David Yellin Academic College of Education, Jerusalem, Israel.

Department of Oncology, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

出版信息

BMC Complement Med Ther. 2024 Feb 2;24(1):74. doi: 10.1186/s12906-024-04367-8.

DOI:10.1186/s12906-024-04367-8

PMID:38308248

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10835900/

Abstract

BACKGROUND

Exercise has shown positive effects on fatigue, exhaustion, neuropathy, and quality of life in cancer patients. While on-land exercises have been studied, the aquatic environment offers unique advantages. Water's density and viscosity provide resistance, enhancing muscle strength, while hydrostatic pressure improves venous return. This trial aims to investigate the effect of aquatic exercises on time to return to work, work hours, work-related difficulties, daily life activity and participation, quality of life, exhaustion, fatigue, and neuropathy among cancer patients, compared to on-land exercise intervention group and a non-exercise group.

METHODS

This randomized controlled trial will include 150 cancer patients aged 18-65 years with stage III colon cancer or breast cancer patients with lymph node involvement. Participants in the aquatic exercise intervention group will undergo an 8-week, twice-weekly group-based Ai-Chi program, while the on-land exercise group will perform identical exercise. The control group will not engage in any exercise. The primary outcome will be assessed using an employment barriers questionnaire, capturing return to work date and working hours and daily life participation and activity and quality of life. Secondary outcomes include exhaustion, fatigue, and neuropathy. Data will be collected at baseline, post-intervention (8 weeks), and at 3,12, and 24 months. Mixed variance analyses will explore relationships among groups and over time for independent variables, with separate analyses for each dependent variable.

DISCUSSION

The potential benefits include an earlier return to work for patients, reducing their need for social and economic support. The study's implications on socio-economic policies are noteworthy, as a successful intervention could offer a cost-effective and non-invasive solution, improving patients' quality of life and increasing their participation in daily activities. This, in turn, could lead to a faster return to work, contributing to both personal well-being and broader societal interests by reducing reliance on social services.

TRIAL REGISTRATION

The trial is registered at ClinicalTrials.gov NCT05427344 (22 June 2022).

摘要

背景

运动已被证明对癌症患者的疲劳、乏力、神经病变和生活质量有积极影响。虽然已经研究了陆地运动，但水的环境提供了独特的优势。水的密度和粘性提供阻力，增强肌肉力量，而静水压力改善静脉回流。本试验旨在研究与陆地运动干预组和非运动组相比，水上运动对癌症患者重返工作岗位的时间、工作时间、与工作相关的困难、日常生活活动和参与、生活质量、乏力、疲劳和神经病变的影响。

方法

本随机对照试验将纳入 150 名年龄在 18-65 岁之间的 III 期结肠癌或淋巴结受累的乳腺癌患者。水上运动干预组的参与者将接受 8 周、每周两次的集体 Ai-Chi 方案，而陆地运动组将进行相同的运动。对照组将不进行任何运动。主要结局将使用就业障碍问卷进行评估，记录重返工作日期和工作时间以及日常生活参与和活动以及生活质量。次要结局包括乏力、疲劳和神经病变。数据将在基线、干预后（8 周）以及 3、12 和 24 个月时收集。混合方差分析将探索组间和随时间的关系，对于自变量进行单独分析，对于每个因变量进行单独分析。

讨论

潜在的好处包括患者更早地重返工作岗位，减少他们对社会和经济支持的需求。该研究对社会经济政策具有重要意义，因为成功的干预措施可能提供一种具有成本效益和非侵入性的解决方案，提高患者的生活质量并增加他们对日常活动的参与。这反过来又可以促进更快地重返工作岗位，通过减少对社会服务的依赖，促进个人福祉和更广泛的社会利益。