School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
Beijing Laboratory for Food Quality and Safety, Beijing Technology and Business University, Beijing, China.
J Sci Food Agric. 2024 Jul;104(9):5244-5251. doi: 10.1002/jsfa.13348. Epub 2024 Feb 21.
Sturgeon is a popular aquaculture species in many countries. Its swim bladder is rich in collagen but has not yet been exploited scientifically.
Collagen peptides (CPs) prepared from sturgeon swim bladder by trypsinolysis had an average molecular weight of 528.5 Da and consisted of 407 peptides, 16.1% of the content of which was GFPGADGSAGPK. The CPs at 25 mg mL extended the lifespan of Caenorhabditis elegans by 22.6%, which was significantly higher than the extension achieved by other hydrolysis methods and source materials. They also improved fitness-related traits (body size, motor capacity, oxidative stress, cell apoptosis, and epidermal barrier function), indicating prolonged healthspan. Transcriptome analysis showed that the effect was mediated by the mitogen-activated protein kinase pathway, which enhanced stress resistance, the insulin/IGF-1 pathway, which inhibited protein aggregation, and the NHR-80/FAT-6 pathway, which regulated lipid metabolism.
Collagen peptides from sturgeon swim bladder by trypsinolysis prolonged the lifespan and healthspan in C. elegans, and might be promising anti-aging agents. © 2024 Society of Chemical Industry.
鲟鱼是许多国家受欢迎的水产养殖品种。其鱼鳔富含胶原蛋白，但尚未得到科学开发。
通过胰蛋白酶解从鲟鱼鱼鳔制备的胶原蛋白肽（CPs）的平均分子量为 528.5 Da，由 407 个肽组成，其中 16.1%的序列为 GFPGADGSAGPK。25 mg/mL 的 CPs 可将秀丽隐杆线虫的寿命延长 22.6%，明显高于其他水解方法和来源材料的延长效果。它们还改善了与健康相关的特征（体型、运动能力、氧化应激、细胞凋亡和表皮屏障功能），表明健康寿命延长。转录组分析表明，这种作用是通过丝裂原活化蛋白激酶途径介导的，该途径增强了应激抗性，胰岛素/IGF-1 途径抑制了蛋白质聚集，NHR-80/FAT-6 途径调节了脂质代谢。
胰蛋白酶解鲟鱼鱼鳔胶原蛋白肽可延长秀丽隐杆线虫的寿命和健康寿命，可能是有前途的抗衰老剂。 © 2024 化学工业协会。
