Centre for Biostatistics, Division of Population Health, Health Services Research, and Primary Care, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Centre for Biostatistics, Division of Population Health, Health Services Research, and Primary Care, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.
Fertil Steril. 2024 Jun;121(6):918-920. doi: 10.1016/j.fertnstert.2024.01.034. Epub 2024 Feb 1.
When evidence from randomized controlled trials about the effectiveness and safety of an intervention is unclear, researchers may choose to review the nonrandomized evidence. All systematic reviews pose considerable challenges, and the level of methodological expertise required to undertake a useful review of nonrandomized intervention studies is both high and often severely underestimated. Using the example of the endometrial receptivity array, we review some common, critical flaws in systematic reviews of this nature, including errors in critical appraisal and meta-analysis.
当干预措施的有效性和安全性的随机对照试验证据不明确时，研究人员可能会选择审查非随机证据。所有系统评价都面临着相当大的挑战，而且进行有用的非随机干预研究系统评价所需的方法学专业知识水平既高，而且往往严重低估。我们以子宫内膜容受性阵列为例，回顾了此类系统评价中一些常见的、关键的缺陷，包括关键评估和荟萃分析中的错误。
