The Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioengineering, University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX, 75080-3021, USA.
Sci Rep. 2024 Feb 3;14(1):2833. doi: 10.1038/s41598-024-53522-1.
Wearable devices can non-invasively monitor patients with chronic diseases. Sweat is an easily accessible biofluid for continuous sampling of analytes, including inflammatory markers and cytokines. We evaluated a sweat sensing wearable device in subjects with and without inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract. Participants with an IBD related hospital admission and a C-reactive protein level above 5 mg/L wore a sweat sensing wearable device for up to 5 days. Tumor necrosis factor-alpha (TNF-α) levels were continually assessed in the sweat via the sensor, and daily in the blood. A second cohort of healthy subjects without chronic diseases wore the device for up to 48 h. Twenty-eight subjects were enrolled. In the 16 subjects with IBD, a moderate linear relationship between serum and sweat TNF-α levels was observed (R = 0.72). Subjects with IBD were found to have a mean sweat TNF-α level of 2.11 pg/mL, compared to a mean value of 0.19 pg/mL in 12 healthy controls (p < 0.0001). Sweat TNF-α measurements differentiated subjects with active IBD from healthy subjects with an AUC of 0.962 (95% CI 0.894-1.000). A sweat sensing wearable device can longitudinally measure key sweat-based markers of IBD. TNF-α levels in the sweat of subjects with IBD correlate with serum values, suggesting feasibility in non-invasive disease monitoring.
可穿戴设备可以无创监测慢性疾病患者。汗液是一种易于获取的生物流体，可用于连续采样分析物，包括炎症标志物和细胞因子。我们评估了一种用于患有和不患有炎症性肠病（IBD）的受试者的汗液感应可穿戴设备，IBD 是一种胃肠道的慢性炎症性疾病。有 IBD 相关住院和 C 反应蛋白水平高于 5mg/L 的患者佩戴汗液感应可穿戴设备长达 5 天。通过传感器持续评估汗液中的肿瘤坏死因子-α（TNF-α）水平，并在血液中每天评估一次。第二组无慢性疾病的健康受试者佩戴该设备长达 48 小时。共纳入 28 名受试者。在 16 名 IBD 患者中，观察到血清和汗液 TNF-α 水平之间存在中度线性关系（R=0.72）。与 12 名健康对照者的平均汗液 TNF-α 水平 0.19pg/mL 相比，IBD 患者的平均汗液 TNF-α 水平为 2.11pg/mL（p<0.0001）。汗液 TNF-α 测量可区分活动期 IBD 患者和健康对照者，曲线下面积为 0.962（95%CI 0.894-1.000）。一种汗液感应可穿戴设备可以纵向测量 IBD 的关键基于汗液的标志物。IBD 患者汗液中的 TNF-α 水平与血清值相关，表明在非侵入性疾病监测中具有可行性。
