Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, China.
College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Obes Rev. 2024 May;25(5):e13701. doi: 10.1111/obr.13701. Epub 2024 Feb 4.
Melatonin appears to be a promising supplement for obesity treatment. The antiobesity effects of melatonin on obese rodents are influenced by various factors, including the species, sex, the dosage of melatonin, treatment duration, administration via, daily treatment time, and initial body weight (IBW). Therefore, we conducted a meta-analysis and machine learning study to evaluate the antiobesity effect of melatonin on obese mice or rats from 31 publications. The results showed that melatonin significantly reduced body weight, serum glucose (GLU), triglycerides (TGs), low-density lipoprotein (LDL), and cholesterol (TC) levels in obese mice or rats but increased high-density lipoprotein (HDL) levels. Melatonin showed a slight positive effect on clock-related genes, although the number of studies was limited. Meta-regression analysis and machine learning indicated that the dosage of melatonin was the primary factor influencing body weight, with higher melatonin dosages leading to a stronger weight reduction effect. Together, male obese C57BL/6 mice and Sprague-Dawley rats with an IBW of 100-200 g showed better body weight reduction when supplemented with a dose of 10-30 mg/kg melatonin administered at night via injection for 5-8 weeks.
褪黑素似乎是一种很有前途的肥胖治疗补充剂。褪黑素对肥胖啮齿动物的抗肥胖作用受到多种因素的影响，包括物种、性别、褪黑素剂量、治疗持续时间、给药途径、每日治疗时间和初始体重（IBW）。因此，我们进行了一项荟萃分析和机器学习研究，以评估 31 篇文献中褪黑素对肥胖小鼠或大鼠的抗肥胖作用。结果表明，褪黑素可显著降低肥胖小鼠或大鼠的体重、血清葡萄糖（GLU）、甘油三酯（TGs）、低密度脂蛋白（LDL）和胆固醇（TC）水平，但可升高高密度脂蛋白（HDL）水平。褪黑素对时钟相关基因有轻微的正向作用，但研究数量有限。Meta 回归分析和机器学习表明，褪黑素的剂量是影响体重的主要因素，较高的褪黑素剂量可产生更强的减重效果。综上所述，雄性肥胖 C57BL/6 小鼠和初始体重为 100-200 g 的 Sprague-Dawley 大鼠，在夜间通过注射给予 10-30mg/kg 的褪黑素，连续 5-8 周，体重减轻效果更好。
