Katamadze N N, Pigarova E A, Dzeranova L K, Mokrysheva N G
Endocrinology Research Centre.
Probl Endokrinol (Mosk). 2024 Jan 24;69(6):28-36. doi: 10.14341/probl13214.
Age-related changes have a great influence on the regulation of water and electrolyte homeostasis in the body, which is regulated by a complex interaction of environmental factors, drinking behavior, the secretion of a number of hormones and hormone-like substances, as well as the innervation and functional state of the kidneys. It is well known that the changes that are part of physiological aging underlie fluid and electrolyte imbalances, exacerbated by the presence of age-related diseases, medications, or a number of external factors such as malnutrition, fluid intake, and the presence of dementia. This review considers literature data on the effect of normal aging on the development of pathology of the water-sodium balance, including dehydration of senile patients, hyponatremia, hypernatremia, changes in the secretion of antidiuretic hormone and the activity of elements of the renin-angiotensin-aldosterone system.
年龄相关变化对机体水和电解质平衡的调节有很大影响,这种调节受环境因素、饮水行为、多种激素及类激素物质的分泌以及肾脏的神经支配和功能状态等复杂相互作用的调控。众所周知,生理衰老过程中的变化是导致液体和电解质失衡的基础,而与年龄相关的疾病、药物或一些外部因素(如营养不良、液体摄入和痴呆症)的存在会使这种失衡加剧。本综述探讨了关于正常衰老对水钠平衡病理发展影响的文献数据,包括老年患者脱水、低钠血症、高钠血症、抗利尿激素分泌变化以及肾素 - 血管紧张素 - 醛固酮系统各成分的活性变化。