Department of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
Department of Obstetrics and Gynecology, Faculty of Medicine Ain Shams University, Cairo, Egypt.
J Med Life. 2023 Oct;16(10):1482-1487. doi: 10.25122/jml-2023-0283.
The novel Coronavirus disease (COVID-19) is associated with an increased risk of cerebrovascular events. About 1,228 cases of severe COVID-19 were hospitalized in the West Kazakhstan Medical University Hospital, in Aktobe, Kazakhstan, 1.22% (N=15) of whom were clinically diagnosed with acute cerebrovascular events and were included in the current study. COVID-19 was diagnosed using a nasopharyngeal polymerase chain reaction (PCR) test, blood count, inflammatory markers, and chest computerized tomography. The diagnosis of acute cerebrovascular events was based on the clinical manifestation. The participants' data were reviewed to detect the prevalence of acute cerebrovascular events and the inflammatory markers associated with COVID-19 infection. The mean age of the participants was 66.9 years (±11.07), 53% (N=8) of them were male, while 47% (N=7) were female. Moreover, 13% (N=2) presented a history of cerebrovascular events, 87% (N=13) of the participants had hypertension, 47% (N=7) had coronary heart disease, 33% (N=5) had diabetes mellitus (DM), 13% (N=2) had cardiac arrhythmia, and 13% (N=2) had chronic obstructive pulmonary disease (COPD). The C-reactive protein was high in 100% (N=15) of participants, D-dimer in 87% (N=13) of them, and both the ferritin and interleukin-6 were high in 60% (N=9) of the participants. SARS-CoV-2 causes a systemic inflammatory response, and the presence of comorbidities increases the risk of acute cerebrovascular events in COVID-19-infected individuals. The elevated inflammatory markers in severely COVID-19-infected individuals support the inflammatory "cytokine storm" response theory.
新型冠状病毒病（COVID-19）与脑血管事件的风险增加有关。在哈萨克斯坦阿克托贝的西哈萨克斯坦医科大学医院，约有 1228 例严重 COVID-19 住院患者，其中 1.22%（N=15）被临床诊断为急性脑血管事件，并纳入本研究。COVID-19 的诊断采用鼻咽聚合酶链反应（PCR）检测、血常规、炎症标志物和胸部计算机断层扫描。急性脑血管事件的诊断基于临床表现。回顾参与者的数据，以检测 COVID-19 感染相关的急性脑血管事件发生率和炎症标志物。参与者的平均年龄为 66.9 岁（±11.07），53%（N=8）为男性，47%（N=7）为女性。此外，13%（N=2）有脑血管事件史，87%（N=13）有高血压，47%（N=7）有冠心病，33%（N=5）有糖尿病，13%（N=2）有心律失常，13%（N=2）有慢性阻塞性肺疾病（COPD）。100%（N=15）的参与者 C 反应蛋白升高，87%（N=13）的参与者 D-二聚体升高，60%（N=9）的参与者铁蛋白和白细胞介素-6 均升高。SARS-CoV-2 引起全身炎症反应，合并症的存在增加了 COVID-19 感染者发生急性脑血管事件的风险。严重 COVID-19 感染者升高的炎症标志物支持炎症“细胞因子风暴”反应理论。
