Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
J Med Virol. 2020 Oct;92(10):2050-2054. doi: 10.1002/jmv.25989. Epub 2020 May 22.
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China at the end of 2019 has spread throughout the world and caused many thousands of deaths. The previous study reported a higher severe status rate and mortality rate in male patients in China. However, the reason underlying this difference has not been reported. The convalescent plasma containing a high level of SARS-CoV-2 immunoglobulin G (IgG) antibody has been used in clinical therapy and achieved good effects in China. In this study, to compare the differences of the SARS-CoV-2 IgG antibody between male and female patients, a total number of 331 patients confirmed SARS-CoV-2 infection were enrolled. The serum of these patients was collected during hospitalization and detected for the SARS-CoV-2 IgG antibody. Our data showed that the concentration of IgG antibody in mild, general, and recovering patients showed no difference between male and female patients. In severe status, compared with male patients, there were more female patients having a relatively high concentration of serum SARS-CoV-2 IgG antibody. In addition, the generation of IgG antibody in female patients was stronger than male patients in disease early phase. Our study identified a discrepancy in the SARS-CoV-2 IgG antibody level in male and female patients, which may be a potential cause leading to a different outcome of Coronavirus Disease 2019 between sex.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）于 2019 年底在中国出现并蔓延至全球，导致数千人死亡。先前的研究报告称，中国男性患者的严重程度和死亡率更高。然而，造成这种差异的原因尚未报道。含有高浓度 SARS-CoV-2 免疫球蛋白 G（IgG）抗体的恢复期血浆已在中国用于临床治疗，并取得了良好效果。在这项研究中，为了比较男性和女性患者之间 SARS-CoV-2 IgG 抗体的差异，共纳入了 331 名确诊为 SARS-CoV-2 感染的患者。这些患者在住院期间采集血清，并检测 SARS-CoV-2 IgG 抗体。我们的数据显示，在轻症、普通和恢复期患者中，IgG 抗体的浓度在男性和女性患者之间没有差异。在重症患者中，与男性患者相比，有更多的女性患者血清 SARS-CoV-2 IgG 抗体浓度相对较高。此外，在疾病早期，女性患者产生 IgG 抗体的能力强于男性患者。我们的研究发现，男性和女性患者之间 SARS-CoV-2 IgG 抗体水平存在差异，这可能是导致 2019 年冠状病毒病（COVID-19）性别结局不同的潜在原因。
