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Revolutionizing gastric cancer treatment: The potential of immunotherapy.

作者信息

Christodoulidis Grigorios, Koumarelas Konstantinos Eleftherios, Kouliou Marina Nektaria

机构信息

Department of General Surgery, University Hospital of Larissa, Larissa 41110, Greece.

出版信息

World J Gastroenterol. 2024 Jan 28;30(4):286-289. doi: 10.3748/wjg.v30.i4.286.


DOI:10.3748/wjg.v30.i4.286
PMID:38313231
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10835540/
Abstract

Gastric cancer, a prevalent malignancy worldwide, ranks sixth in terms of frequency and third in fatality, causing over a million new cases and 769000 annual deaths. Predominant in Eastern Europe and Eastern Asia, risk factors include family medical history, dietary habits, tobacco use, , and Epstein-Barr virus infections. Unfortunately, gastric cancer is often diagnosed at an advanced stage, leading to a grim prognosis, with a 5-year overall survival rate below 5%. Surgical intervention, particularly with D2 Lymphadenectomy, is the mainstay for early-stage cases but offers limited success. For advanced cases, the National Comprehensive Cancer Network recommends chemotherapy, radiation, and targeted therapy. Emerging immunotherapy presents promise, especially for unresectable or metastatic cases, with strategies like immune checkpoint inhi-bitors, tumor vaccines, adoptive immunotherapy, and nonspecific immunomodulators. In this Editorial, with regards to the article "Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric and clinical trial review", we address the advances in the field of immunotherapy in gastric cancer and its future prospects.

摘要

相似文献

[1]
Revolutionizing gastric cancer treatment: The potential of immunotherapy.

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[2]
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[7]
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[8]
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[9]
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[2]
Progress of immune checkpoint inhibitors in gastric cancer.

World J Gastrointest Oncol. 2025-8-15

[3]
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Sci Rep. 2025-8-12

[4]
Association between emotional distress and the efficacy of advanced gastric cancer patients undergoing treatment with immune checkpoint inhibitors: a cohort study and propensity score matching study.

Front Oncol. 2025-7-25

[5]
Cost-effectiveness analysis of cadonilimab plus chemotherapy as a first-line treatment option in HER-2-negative advanced gastric cancer.

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[6]
Impact of helicobacter pylori infection on the efficacy of ICIs in gastric cancer.

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[7]
Identification of PD-L1-related biomarkers for selecting gastric adenocarcinoma patients for PD-1/PD-L1 inhibitor therapy.

Discov Oncol. 2025-5-8

[8]
Role of cell-based therapies in digestive disorders: Obstacles and opportunities.

Regen Ther. 2025-3-4

[9]
Relationship between gastric mucosal atrophy, cystic dilatation, and histopathological characteristics.

BMC Gastroenterol. 2025-2-18

[10]
DNA methyltransferase 3A: A prognostic biomarker and potential target for immunotherapy in gastric cancer.

Medicine (Baltimore). 2025-2-14

本文引用的文献

[1]
Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric and clinical trial review (1999-2023).

World J Gastroenterol. 2023-10-28

[2]
Evaluation of neoadjuvant immunotherapy plus chemotherapy in Chinese surgically resectable gastric cancer: a pilot study by meta-analysis.

Front Immunol. 2023

[3]
Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.

J Clin Oncol. 2023-3-1

[4]
Comparative efficacy and tolerability of targeted and immunotherapy combined with chemotherapy as first-line treatment for advanced gastric cancer: a Bayesian network meta-analysis.

Sci Rep. 2022-12-20

[5]
Recent Progress and Future Perspectives of Immunotherapy in Advanced Gastric Cancer.

Front Immunol. 2022

[6]
Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer.

NPJ Precis Oncol. 2022-6-3

[7]
The current management and biomarkers of immunotherapy in advanced gastric cancer.

Medicine (Baltimore). 2022-5-27

[8]
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results.

Nat Med. 2022-6

[9]
Cellular immunotherapy in gastric cancer: adoptive cell therapy and dendritic cell-based vaccination.

Immunotherapy. 2022-4

[10]
Phase I clinical trial of adoptive transfer of expanded natural killer cells in combination with IgG1 antibody in patients with gastric or colorectal cancer.

Int J Cancer. 2018-2-14

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