Arango-Franco Carlos A, Rojas Julián, Firacative Carolina, Agudelo Clara Inés, Franco José Luis, Casanova Jean-Laurent, Puel Anne, Lizarazo Jairo, Castañeda Elizabeth, Arias Andrés A
University of Antioquia (UdeA).
University del Rosario.
Res Sq. 2024 Jan 19:rs.3.rs-3873029. doi: 10.21203/rs.3.rs-3873029/v1.
Cryptococcosis is a life-threatening disease caused by or . Autoantibodies (auto-Abs) neutralizing granulocyte-macrophage colony-stimulating factor (GM-CSF) in otherwise healthy adults with cryptococcal meningitis have been described since 2013. We searched for neutralizing auto-Abs in sera from Colombian patients with non-HIV related cryptococcosis in a retrospective national cohort collected from 1997 to 2016.
We reviewed clinical and laboratory records and assessed the presence of neutralizing auto-Abs in 30 HIV (-) adults presenting cryptococcosis (13 by , and 17 by ).
We detected auto-Abs neutralizing GM-CSF in the plasma of 9 out of 13 (69%) patients infected with and 1 out of 17 (6%) patients with .
We report ten Colombian patients with cryptococcosis due to auto-Abs neutralizing GM-CSF. Nine of the ten patients were infected with , and only one with .
隐球菌病是一种由新型隐球菌或格特隐球菌引起的危及生命的疾病。自2013年以来，在患有隐球菌性脑膜炎的健康成年人中发现了中和粒细胞巨噬细胞集落刺激因子（GM-CSF）的自身抗体（自身抗体）。我们在1997年至2016年收集的哥伦比亚非HIV相关隐球菌病患者的回顾性全国队列血清中寻找中和性自身抗体。
我们回顾了临床和实验室记录，并评估了30名患有隐球菌病的HIV（-）成年人（13例由新型隐球菌感染，17例由格特隐球菌感染）中中和性自身抗体的存在情况。
我们在13例新型隐球菌感染患者中的9例（69%）血浆中检测到中和GM-CSF的自身抗体，在17例格特隐球菌感染患者中的1例（6%）血浆中检测到中和GM-CSF的自身抗体。
我们报告了10例因中和GM-CSF的自身抗体导致隐球菌病的哥伦比亚患者。这10例患者中有9例感染了新型隐球菌，只有1例感染了格特隐球菌。
