Corby D G, McCullen A H, Chadwick E W, Decker W J
J Toxicol Clin Toxicol. 1985;23(7-8):489-99. doi: 10.3109/15563658508990652.
We have previously shown that ferrous and ferric ions readily for complexes with magnesium hydroxide [Mg(OH)2] thus reducing the absorption of iron salts from the gastrointestinal tract. The present study answers the following question: what is the optimal dose, time of administration, optimal limit of effectiveness, and potential hazard of this form of therapy. Adult mongrel dogs were administered ferrous sulfate [FeSO4] tablets at a dosage of 650 mg/lb of body weight. Either 30 or 60 minutes later, the dogs were given Mg(OH)2 at either 5 or l0 times the dose of elemental iron. Serum iron concentrations in all animals given Mg(OH)2 were significantly lower (p less than 0.05) than those of control animals. No significant differences were observed regardless of dose or time of administration of Mg(OH)2. Although serum Mg++ concentrations were significantly elevated (p less than 0.05) om all treated animals 4 and 6 hr post iron, no clinical manifestations of hypermagnesemia were observed. These studies demonstrate the effectiveness of Mg(OH)2 in the management of experimental iron intoxication and warrant a controlled clinical trial in humans.
我们之前已经表明，亚铁离子和铁离子很容易与氢氧化镁[Mg(OH)₂]形成络合物，从而减少胃肠道中铁盐的吸收。本研究回答了以下问题：这种治疗方式的最佳剂量、给药时间、最佳疗效限度以及潜在危害是什么。给成年杂种犬按每磅体重650毫克的剂量服用硫酸亚铁[FeSO₄]片。在30或60分钟后，给这些犬服用氢氧化镁，剂量为元素铁剂量的5倍或10倍。所有服用氢氧化镁的动物血清铁浓度均显著低于对照动物（p<0.05）。无论氢氧化镁的剂量或给药时间如何，均未观察到显著差异。尽管在给铁后4小时和6小时，所有接受治疗的动物血清镁离子浓度均显著升高（p<0.05），但未观察到高镁血症的临床表现。这些研究证明了氢氧化镁在治疗实验性铁中毒方面的有效性，值得在人体上进行对照临床试验。
