Wallace K L, Curry S C, LoVecchio F, Raschke R A
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, AZ, USA.
Acad Emerg Med. 1998 Oct;5(10):961-5. doi: 10.1111/j.1553-2712.1998.tb02771.x.
To determine the effect of oral magnesium hydroxide [Mg(OH)2] on iron absorption after simulated iron overdose in human subjects.
A randomized, controlled crossover study was conducted in healthy adult male human volunteers taking no medications. Subjects received an average of 5.0 mg/kg elemental iron orally followed 1 hour later by either oral administration of 4.5 g of Mg(OH)2 per g ingested elemental iron or no treatment. Serial serum specimens were obtained over the 12 hours following iron ingestion and stored at -60 degrees C until standard serum iron assay was performed. After a 2-week washout period, the subjects were enrolled in the alternative trial arm. Individual baseline diurnal variation in serum iron levels was determined over a 12-hour period on the day prior to each trial. Area under time-concentration curves (AUCs) were calculated, and the AUC due to experimental iron ingestion (deltaAUC) was determined by subtracting the baseline diurnal AUC from the experimental AUC for each subject.
Thirteen healthy adult male subjects were enrolled. Mean +/- SEM for deltaAUC due to experimental iron ingestion followed by treatment with Mg(OH)2, 78 +/- 23 micromol(hr)/L, was significantly less than that followed by no treatment, 144 +/- 33 micromol(hr)/L (p = 0.03 by signed rank test).
Magnesium hydroxide, administered 1 hour post-iron ingestion at an oral dose of 4.5 g per g elemental iron ingested, significantly reduced iron absorption during a 12-hour period following simulated mild iron overdose in healthy adult human volunteers.
确定口服氢氧化镁[Mg(OH)₂]对人体模拟铁过量摄入后铁吸收的影响。
对未服用任何药物的健康成年男性志愿者进行了一项随机对照交叉研究。受试者口服平均5.0mg/kg元素铁，1小时后，每摄入1g元素铁口服给予4.5g Mg(OH)₂，或不进行治疗。在摄入铁后的12小时内采集系列血清标本，并在-60℃保存，直至进行标准血清铁测定。经过2周的洗脱期后，受试者进入另一个试验组。在每次试验前一天的12小时内测定个体血清铁水平的基线日变化。计算时间-浓度曲线下面积（AUC），每个受试者的试验性铁摄入引起的AUC（δAUC）通过从试验AUC中减去基线日AUC来确定。
招募了13名健康成年男性受试者。试验性铁摄入后用Mg(OH)₂治疗引起的δAUC的平均值±标准误为78±23μmol(hr)/L，显著低于未治疗组的144±33μmol(hr)/L（符号秩检验，p = 0.03）。
在健康成年志愿者模拟轻度铁过量摄入后的12小时内，铁摄入后1小时口服给予每摄入1g元素铁4.5g的氢氧化镁，可显著降低铁的吸收。
