异源杂交瘤中的 A 型逆转录病毒颗粒：人单克隆抗体纯化的注意事项。
Type-A retrovirus particles in heterohybridomas: precaution for human monoclonal antibody purification.
作者信息
Herr J C, Spell D R
出版信息
J Ultrastruct Res. 1985 Jul-Aug;92(1-2):80-5. doi: 10.1016/0889-1605(85)90130-2.
PMID:3831387
Abstract
Fine structural features of the murine myeloma MHFP-1 and two heterohybridomas secreting human IgM monoclonal antibody were examined. Intracisternal type-A retrovirus particles were found in both MHFP-1 and the heterohydribomas constructed by fusing MHFP-1 and human peripheral blood lymphocytes. The implications of this finding for the purification of human monoclonal antibody for therapeutic applications is discussed.
摘要
对小鼠骨髓瘤MHFP-1以及两种分泌人IgM单克隆抗体的异源杂交瘤的精细结构特征进行了检查。在MHFP-1以及通过将MHFP-1与人外周血淋巴细胞融合构建的异源杂交瘤中均发现了A型内池逆转录病毒颗粒。讨论了这一发现对于治疗应用中人类单克隆抗体纯化的意义。
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