Department of Vascular Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China.
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, People's Republic of China.
J Biomed Mater Res A. 2024 Jul;112(7):988-1003. doi: 10.1002/jbm.a.37679. Epub 2024 Feb 6.
Acute pancreatitis (AP) is a common and serious acute inflammatory disease with high severity rate and mortality. Inflammation and oxidative stress play an extremely important role in the development of AP disease. Polyvinylpyrrolidone-modified iridium nanoparticles (IrNP-PVP) have multienzyme mimetic activity, and the aim of this article is to discuss the therapeutic alleviative effects of the ultrasmall nanozymes IrNP-PVP on AP through their antioxidant and anti-inflammatory effects. IrNP-PVP were proved to inhibit inflammation and scavenge reactive oxygen species (ROS) at the cellular level. The synthetic IrNP-PVP exhibit remarkable antioxidant and anti-inflammatory activities in the prevention and treatment of AP mice by establishing murine AP model, which can reduce the oxidative stress and inflammatory response. The results of this article indicated that the ultrasmall nanozymes IrNP-PVP effectively alleviate AP via scavenging ROS as well as suppressing inflammation both in vivo and in vitro, which might provide enormous promise for the AP management.
急性胰腺炎（AP）是一种常见且严重的急性炎症性疾病，具有较高的严重程度和死亡率。炎症和氧化应激在 AP 疾病的发展中起着极其重要的作用。聚乙烯吡咯烷酮修饰的铱纳米粒子（IrNP-PVP）具有多酶模拟活性，本文旨在通过其抗氧化和抗炎作用探讨超小纳米酶 IrNP-PVP 对 AP 的治疗缓解作用。IrNP-PVP 已被证明可在细胞水平上抑制炎症和清除活性氧（ROS）。通过建立小鼠 AP 模型，合成的 IrNP-PVP 在预防和治疗小鼠 AP 中表现出显著的抗氧化和抗炎活性，可减轻氧化应激和炎症反应。本文结果表明，超小纳米酶 IrNP-PVP 通过清除 ROS 以及抑制体内外的炎症反应有效缓解 AP，这为 AP 的治疗提供了巨大的希望。
