新冠病毒的持续存在及其在长新冠中的作用。

The Persistence of SARS-CoV-2 and Its Role in Long Covid.

机构信息

QIMR Berghofer Centre for Immunotherapy and Vaccine Development and Translational and Human Immunology Laboratory, Infection and Inflammation Program, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

出版信息

NEJM Evid. 2023 Sep;2(9):EVIDe2300165. doi: 10.1056/EVIDe2300165. Epub 2023 Aug 22.

DOI:10.1056/EVIDe2300165

PMID:38320192

Abstract

Postacute sequelae of coronavirus disease 2019 (PASC), more commonly known as long Covid, manifests as ongoing symptoms in various organs of the body more than 4 weeks after the resolution of acute Covid-19. A prevalent symptom of PASC is an ongoing loss of taste, but additional persisting symptoms can include neurologic, gastrointestinal, kidney, lung, or heart dysfunction. There are two broad mechanisms that are thought to underpin the ongoing complications associated with PASC: dysregulated production of inflammatory cytokines and the persistence of virus..

摘要

新型冠状病毒疾病 2019（COVID-19）的急性后遗症（PASC），通常被称为长新冠，是指在急性 COVID-19 痊愈后 4 周以上身体各器官持续出现症状。PASC 的一个普遍症状是持续失去味觉，但其他持续存在的症状可能包括神经、胃肠道、肾脏、肺部或心脏功能障碍。目前认为有两种广泛的机制可以解释与 PASC 相关的持续并发症：炎症细胞因子的失调产生和病毒的持续存在。