Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
Departmemt of Clinical Laboratory Medicine, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, 226361, China.
Adv Mater. 2024 May;36(19):e2310318. doi: 10.1002/adma.202310318. Epub 2024 Feb 20.
Neutrophils are the most abundant white blood cells in the circulation and act as the first line of defense against infections. Increasing evidence suggests that neutrophils possess heterogeneous phenotypes and functional plasticity in human health and diseases, including cancer. Neutrophils play multifaceted roles in cancer development and progression, and an N1/N2 paradigm of neutrophils in cancer is proposed, where N1 neutrophils exert anti-tumor properties while N2 neutrophils display tumor-supportive and immune-suppressive functions. Selective activation of beneficial neutrophil population and targeted inhibition or re-polarization of tumor-promoting neutrophils has shown an important potential in tumor therapy. In addition, due to the natural inflammation-responsive and physical barrier-crossing abilities, neutrophils and their derivatives (membranes and extracellular vesicles (EVs)) are regarded as advanced drug delivery carriers for enhanced tumor targeting and improved therapeutic efficacy. In this review, the recent advances in engineering neutrophils for drug delivery and targeting neutrophils for remodeling tumor microenvironment (TME) are comprehensively presented. This review will provide a broad understanding of the potential of neutrophils in cancer therapy.
中性粒细胞是循环中最丰富的白细胞，是抵御感染的第一道防线。越来越多的证据表明，中性粒细胞在人类健康和疾病（包括癌症）中具有异质表型和功能可塑性。中性粒细胞在癌症的发生和发展中发挥着多方面的作用，提出了中性粒细胞在癌症中的 N1/N2 范式，其中 N1 中性粒细胞发挥抗肿瘤特性，而 N2 中性粒细胞则具有肿瘤支持和免疫抑制功能。选择性激活有益的中性粒细胞群体，并靶向抑制或重新极化促进肿瘤的中性粒细胞，在肿瘤治疗中显示出重要的潜力。此外，由于具有天然的炎症反应和物理屏障穿透能力，中性粒细胞及其衍生物（膜和细胞外囊泡（EVs））被认为是先进的药物递送载体，可增强肿瘤靶向性并提高治疗效果。在这篇综述中，全面介绍了用于药物递送的中性粒细胞工程和针对重塑肿瘤微环境（TME）的中性粒细胞靶向的最新进展。这篇综述将为理解中性粒细胞在癌症治疗中的潜力提供广泛的认识。
