有无冠状动脉血管舒缩功能障碍的无阻塞性冠状动脉疾病（ANOCA）患者存在有限的心电图重塑。
ANOCA patients with and without coronary vasomotor dysfunction present with limited electrocardiographic remodeling.
作者信息
Schipaanboord Diantha J M, Jansen Tijn P J, Crooijmans Caïa, Onland-Moret N Charlotte, Elias-Smale Suzette E, Dimitriu-Leen Aukelien C, van der Harst Pim, van de Hoef Tim P, van Es René, Damman Peter, den Ruijter Hester M
机构信息
Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands.
出版信息
Int J Cardiol Heart Vasc. 2024 Jan 31;50:101347. doi: 10.1016/j.ijcha.2024.101347. eCollection 2024 Feb.
BACKGROUND
Coronary vasomotor dysfunction (CVDys) comprises coronary vasospasm (CVS) and/or coronary microvascular dysfunction (CMD) and is highly prevalent in patients with angina and non-obstructive coronary artery disease (ANOCA). Invasive coronary function testing (CFT) to diagnose CVDys is becoming more common, enabling pathophysiologic research of CVDys. This study aims to explore the electrophysiological characteristics of ANOCA patients with CVDys.
METHODS
We collected pre-procedural 12-lead electrocardiograms of ANOCA patients with CVS (n = 35), CMD (n = 24), CVS/CMD (n = 26) and patients without CVDys (CFT-, n = 23) who participated in the NL-CFT registry and underwent CFT. Heart axis and conduction times were compared between patients with CVS, CMD or CVS/CMD and patients without CVDys.
RESULTS
Heart axis, heart rate, PQ interval and QRS duration were comparable between the groups. A small prolongation of the QT-interval corrected with Bazett (QTcB) and Fridericia (QTcF) was observed in patients with CVDys compared to patients without CVDys (CVS vs CFT-: QTcB = 422 ± 18 vs 414 ± 18 ms (p = 0.14), QTcF = 410 ± 14 vs 406 ± 12 ms (p = 0.21); CMD vs CFT-: QTcB = 426 ± 17 vs 414 ± 18 ms (p = 0.03), QTcF = 413 ± 11 vs 406 ± 12 ms (p = 0.04); CVS/CMD vs CFT-: QTcB = 424 ± 17 vs 414 ± 18 ms (p = 0.05), QTcF = 414 ± 14 vs 406 ± 12 ms (p = 0.04)).
CONCLUSIONS
Pre-procedural 12-lead electrocardiograms were comparable between patients with and without CVDys undergoing CFT except for a slightly longer QTc interval in patients with CVDys compared to patients without CVDys, suggesting limited cardiac remodeling in patients with CVDys.
背景
冠状动脉血管运动功能障碍（CVDys）包括冠状动脉痉挛（CVS）和/或冠状动脉微血管功能障碍（CMD），在心绞痛和非阻塞性冠状动脉疾病（ANOCA）患者中高度流行。用于诊断CVDys的侵入性冠状动脉功能测试（CFT）越来越普遍，这有助于对CVDys进行病理生理学研究。本研究旨在探讨患有CVDys的ANOCA患者的电生理特征。
方法
我们收集了参与NL-CFT注册研究并接受CFT的患有CVS（n = 35）、CMD（n = 24）、CVS/CMD（n = 26）的ANOCA患者以及无CVDys患者（CFT阴性，n = 23）的术前12导联心电图。比较了患有CVS、CMD或CVS/CMD的患者与无CVDys患者的心脏轴和传导时间。
结果
各组之间的心脏轴、心率、PQ间期和QRS时限相当。与无CVDys的患者相比，患有CVDys的患者经Bazett法校正的QT间期（QTcB）和经Fridericia法校正的QT间期（QTcF）有轻微延长（CVS组与CFT阴性组比较：QTcB = 422±18 vs 414±18毫秒（p = 0.14），QTcF = 410±14 vs 406±12毫秒（p = 0.21）；CMD组与CFT阴性组比较：QTcB = 426±17 vs 414±18毫秒（p = 0.03），QTcF = 413±11 vs 406±12毫秒（p = 0.04）；CVS/CMD组与CFT阴性组比较：QTcB = 424±17 vs 414±18毫秒（p = 0.05），QTcF = 414±14 vs 406±12毫秒（p = 0.04））。
结论
接受CFT的有和无CVDys的患者术前12导联心电图相当，只是患有CVDys的患者QTc间期比无CVDys的患者略长，这表明患有CVDys的患者心脏重塑有限。
Zotero 插件