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Viral clearance as a surrogate of clinical efficacy for COVID-19 therapies in outpatients: a systematic review and meta-analysis.门诊 COVID-19 治疗中病毒清除作为临床疗效替代指标的系统评价和荟萃分析。
Lancet Microbe. 2024 May;5(5):e459-e467. doi: 10.1016/S2666-5247(23)00398-1. Epub 2024 Apr 4.
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Statistical Challenges When Analyzing SARS-CoV-2 RNA Measurements Below the Assay Limit of Quantification in COVID-19 Clinical Trials.在 COVID-19 临床试验中分析低于定量分析检测限的 SARS-CoV-2 RNA 测量值时面临的统计挑战。
J Infect Dis. 2023 Aug 31;228(Suppl 2):S101-S110. doi: 10.1093/infdis/jiad285.
3
Association Between Anterior Nasal and Plasma SARS-CoV-2 RNA Levels and Hospitalization or Death in Nonhospitalized Adults With Mild-to-Moderate COVID-19.非住院的轻至中度 COVID-19 成人患者的前鼻拭子和血浆 SARS-CoV-2 RNA 水平与住院或死亡的相关性。
J Infect Dis. 2023 Aug 31;228(Suppl 2):S117-S125. doi: 10.1093/infdis/jiad287.
4
Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19.在非住院的 COVID-19 患者中,组合 SARS-CoV-2 中和单克隆抗体 Amubarvimab 加 Romlusevimab 的安全性和疗效。
Ann Intern Med. 2023 May;176(5):658-666. doi: 10.7326/M22-3428. Epub 2023 Apr 18.
5
Clinical relevance of nasopharyngeal SARS-CoV-2 viral load reduction in outpatients with COVID-19.新冠门诊患者鼻咽部严重急性呼吸综合征冠状病毒2(SARS-CoV-2)病毒载量降低的临床相关性
J Antimicrob Chemother. 2022 Jun 29;77(7):2038-2039. doi: 10.1093/jac/dkac104.
6
Meta-analysis for the evaluation of potential surrogate markers.用于评估潜在替代标志物的Meta分析。
Stat Med. 1997 Sep 15;16(17):1965-82. doi: 10.1002/(sici)1097-0258(19970915)16:17<1965::aid-sim630>3.0.co;2-m.
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Evaluating surrogate markers.评估替代标志物。
J Acquir Immune Defic Syndr Hum Retrovirol. 1995;10 Suppl 2:S1-8.

Response to Drs de Grooth and Parienti.

作者信息

Giganti Mark J, Chew Kara W, Eron Joseph J, Smith Davey M, Currier Judith S, Hughes Michael D

机构信息

Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

出版信息

J Infect Dis. 2024 May 15;229(5):1596. doi: 10.1093/infdis/jiae053.

DOI:10.1093/infdis/jiae053
PMID:38324658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11491825/
Abstract
摘要