Department of Orthopedic Surgery, Institute of Orthopedics, The First Affiliated Hospital of Soochow University, Soochow University, Jiangsu, China.
Department of Orthopedic Surgery and Biochemistry, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
Lipids Health Dis. 2024 Feb 7;23(1):38. doi: 10.1186/s12944-024-02033-z.
While lipid metabolism disorder is widely acknowledged as a contributing factor to inflammation, the association between remnant cholesterol (RC), which indicates lipid metabolism, and rheumatoid arthritis (RA) has not been investigated. Accordingly, this study evaluated whether RC is associated with RA disease events.
Data were collected and specifically extracted from the National Health and Nutrition Examination Survey (NHANES) 1999-2008 database. The RC value was derived by subtracting the combined amount of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) from the total cholesterol (TC). The association between RC and RA was evaluated using multivariate regression analysis and subgroup analysis.
The study analyzed 7777 patients, of which 581 patients (7.47%) were diagnosed with RA. After accounting for different covariates, the multivariate logistic regression analysis revealed a notable correlation between increased RC levels and an increased likelihood of RA (odds ratio OR = 1.54; 95% confidence interval CI: 1.11-2.13; P = 0.0092). The interaction test did not yield statistically significant effects on this association. The linear correlation between RC and RA was observed within restricted cubic spline regression model limitations.
The results suggest that higher RC levels are associated with increased odds of RA, indicating that RC can serve as a novel and convenient index for forecasting the likelihood of RA in the United States. Additionally, these findings offer insights into early intervention strategies for susceptible populations at risk of developing RA.
虽然脂质代谢紊乱被广泛认为是炎症的一个促成因素，但残胆固醇（RC）与类风湿关节炎（RA）之间的关联尚未得到研究。因此，本研究评估了 RC 是否与 RA 疾病事件相关。
从 1999-2008 年全国健康和营养调查（NHANES）数据库中收集并专门提取数据。RC 值通过从总胆固醇（TC）中减去低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）的总和得出。使用多变量回归分析和亚组分析评估 RC 与 RA 之间的关联。
该研究分析了 7777 名患者，其中 581 名（7.47%）被诊断为 RA。在考虑了不同的协变量后，多变量逻辑回归分析显示 RC 水平升高与 RA 发生的可能性增加之间存在显著相关性（优势比 OR=1.54；95%置信区间 CI：1.11-2.13；P=0.0092）。交互检验对这种关联没有统计学意义。RC 和 RA 之间的线性相关性在限制立方样条回归模型限制内观察到。
结果表明，RC 水平升高与 RA 发生的几率增加相关，表明 RC 可作为预测美国 RA 发生可能性的新的、方便的指标。此外，这些发现为易患 RA 的高危人群提供了有关早期干预策略的见解。
