Wang Yuxuan, Li Hao, Zhang Zhihao, Wu Futong, Liu Jiarui, Zhu Zhongze, Xiang Hongfei
Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China.
Clinical Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong, 266000, China.
Lipids Health Dis. 2024 Oct 1;23(1):325. doi: 10.1186/s12944-024-02313-8.
Blood lipid profiles are associated with various nutritional elements and dietary factors. This study aimed to explore the association between total dietary vitamin E intake and remnant cholesterol (RC), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) using data from the National Health and Nutrition Examination Survey (NHANES).
A cross-sectional analysis was conducted using NHANES 2007-2018 data. A total of 8,639 eligible participants (45.58% men and 54.42% women) with an average age of 46.12 ± 16.65 years were included in this study. Weighted multivariate linear regression and subgroup analyses were used to examine the association between vitamin E intake and RC, TC, HDL-C, and LDL-C. Smooth curve fitting was used to explore potential non-linear associations.
After adjusting for other covariates, multivariate linear regression analysis showed that higher vitamin E intake was negatively associated with plasma RC (β = -0.22, 95% CI: -0.27, -0.16), TC (β = -0.33, 95% CI: -0.51, -0.16), LDL-C (β = -0.25, 95% [confidence interval] CI: -0.40, -0.10) and positively associated with HDL-C (β = 0.13, 95% CI: 0.07, 0.20) in US adults. Subgroup analysis indicated that age may influence the association between vitamin E intake and RC. At the same time, gender may also affect the association between vitamin E intake and HDL-C.
Higher vitamin E intake was negatively associated with plasma RC, TC, LDL-C and positively associated with HDL-C.
血脂谱与多种营养元素和饮食因素相关。本研究旨在利用美国国家健康与营养检查调查（NHANES）的数据，探讨膳食维生素E总摄入量与残余胆固醇（RC）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）之间的关联。
使用NHANES 2007 - 2018年的数据进行横断面分析。本研究纳入了8639名符合条件的参与者（男性占45.58%，女性占54.42%），平均年龄为46.12±16.65岁。采用加权多元线性回归和亚组分析来检验维生素E摄入量与RC、TC、HDL-C和LDL-C之间的关联。使用平滑曲线拟合来探索潜在的非线性关联。
在调整其他协变量后，多元线性回归分析显示，在美国成年人中，较高的维生素E摄入量与血浆RC（β = -0.22，95%置信区间：-0.27，-0.16）、TC（β = -0.33，95%置信区间：-0.51，-0.16）、LDL-C（β = -0.25，95%置信区间：-0.40，-0.10）呈负相关，与HDL-C（β = 0.13，95%置信区间：0.07，0.20）呈正相关。亚组分析表明，年龄可能影响维生素E摄入量与RC之间的关联。同时，性别也可能影响维生素E摄入量与HDL-C之间的关联。
较高的维生素E摄入量与血浆RC、TC、LDL-C呈负相关，与HDL-C呈正相关。
