Filardi M J, Codish S D, Civerchia L, Howard R K, McKneally M F
Cancer Res. 1979 Sep;39(9):3673-6.
The toxicity of intrapleural Tice strain Bacillus Calmette-Guérin (BCG) infection was tested in hamsters. Doses above 10(6) colony-forming units caused significant systemic infection, which could be controlled with conventional antituberculosis therapy. Living BCG in the pleural space did not prevent the healing of bronchial or vascular closures after pulmonary resection. Prophylactic intrapleural BCG (10(6) colony-forming units) significantly reduced tumor growth in the lungs of mice following i.v. injection of 5 x 10(5) syngeneic sarcoma cells. These animal experiments suggest that intrapleural BCG may be administered in the pleural space after lung resection in limited doses if followed by a complementary course of antimicrobial therapy.
对仓鼠进行了胸膜内注射Tice株卡介苗（BCG）感染的毒性试验。剂量高于10⁶集落形成单位会引起明显的全身感染，可通过传统抗结核疗法加以控制。胸膜腔内的活卡介苗并不能阻止肺切除术后支气管或血管闭塞的愈合。预防性胸膜内注射卡介苗（10⁶集落形成单位）可显著降低静脉注射5×10⁵个同基因肉瘤细胞后小鼠肺部肿瘤的生长。这些动物实验表明，肺切除术后可在胸膜腔内以有限剂量注射卡介苗，但之后需辅以一个疗程的抗菌治疗。
